A randomized trial of energy‐restricted high‐protein versus high‐carbohydrate, low‐fat diet in morbid obesity. (13th April 2013)

• Record Type: Journal Article
• Authors: Dalle Grave, Riccardo; Calugi, Simona; Gavasso, Ilaria; El Ghoch, Marwan; Marchesini, Giulio
• Is Part Of: Obesity. Volume 21:Number 9(2013:Sep.)
• Page Start: 1774
• Page End: 1781
• Publication Date: 2013-04-13
• Subjects: Obesity -- Periodicals; 616.398005
• DOI: 10.1002/oby.20320
• Languages: English
• ISSNs: 1930-7381

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="oby20320-sec-0001" sec-type="section"> <title>Objective</title> <p>Conflicting evidence exists as to weight loss produced by diets with different carbohydrate/protein ratio. The aim was to compare the long‐term effects of high‐protein vs. high‐carbohydrate diet (HPD, HCD), combined with cognitive behavior therapy (CBT).</p> </sec> <sec id="oby20320-sec-0002" sec-type="section"> <title>Design and Methods</title> <p>In a randomized trial, 88 obese participants (mean age, 46.7; mean BMI, 45.6 kg m<sup>−2</sup>) were enrolled in a 3‐week inpatient and 48‐week outpatient treatment, with continuous CBT during the study period. All subjects consumed a restricted diet (1, 200 kcal day<sup>−1</sup> for women, 1, 500 for men; 20% energy from fat, <10% saturated fat). HPD derived 34% energy from proteins, 46% from carbohydrates; HCD 17% from proteins, 64% from carbohydrates. The primary outcome was 1‐year percent weight loss. Secondary outcomes were attrition rates and changes in cardiovascular risk factors and psychological profile.</p> </sec> <sec id="oby20320-sec-0003" sec-type="section"> <title>Results</title> <p>Attrition rates were similar between groups (25.6%). In the intention‐to‐treat analysis, weight loss averaged 15.0% in HPD and 13.3% in HCD at 1 year, without any difference throughout the study period. Both diets produced a similar improvement in secondary outcomes.</p> </sec> <sec id="oby20320-sec-0004" sec-type="section"> <title>Conclusions</title> <p>The relative carbohydrate and protein content of the diet, when combined with intensive CBT, does not significantly affect attrition rate, weight loss and psychosocial outcome in patients with severe obesity.</p> </sec> </abstract>