An assay that may predict the development of IgG enhancing allergen‐specific IgE binding during birch immunotherapy. Issue 9 (3rd September 2013)

• Record Type: Journal Article
• Authors: Selb, R.; Eckl‐Dorna, J.; Vrtala, S.; Valenta, R.; Niederberger, V.
• Is Part Of: Allergy. Volume 68:Issue 9(2013:Sep.)
• Page Start: 1199
• Page End: 1202
• Publication Date: 2013-09-03
• Subjects: Allergy -- Periodicals; 616.97
• DOI: 10.1111/all.12204
• Languages: English
• ISSNs: 0105-4538

Abstract

<abstract abstract-type="main" id="all12204-abs-0001"> <title>Abstract</title> <sec id="all12204-sec-0001" sec-type="section"> <title>Background</title> <p>It has been shown that birch pollen immunotherapy can induce IgG antibodies which enhance IgE binding to Bet v 1. We aimed to develop a serological assay to predict the development of antibodies which enhance IgE binding to Bet v 1 during immunotherapy.</p> </sec> <sec id="all12204-sec-0002" sec-type="section"> <title>Methods</title> <p>In 18 patients treated by Bet v 1‐fragment‐specific immunotherapy, the effects of IgG antibodies specific for the fragments on the binding of IgE antibodies to Bet v 1 were measured by ELISA. Blocking and possible enhancing effects on IgE binding were compared with skin sensitivity to Bet v 1 after treatment.</p> </sec> <sec id="all12204-sec-0003" sec-type="section"> <title>Results</title> <p>We found that fragment‐specific IgG enhanced IgE binding to Bet v 1 in two patients who also showed an increase of skin sensitivity to Bet v 1.</p> </sec> <sec id="all12204-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Our results indicate that it may be possible to develop serological tests which predict the induction of unfavourable IgG antibodies enhancing the binding of IgE to Bet v 1 during immunotherapy.</p> </sec> </abstract>