Vitamin D and Type 2 diabetes mellitus (维生素D与2型糖尿病). (28th May 2013)

• Record Type: Journal Article
• Authors: Xuan, Yan; Zhao, Hong‐yan; Liu, Jian‐Min
• Is Part Of: Journal of diabetes. Volume 5:Number 3(2013:Jul.)
• Page Start: 261
• Page End: 267
• Publication Date: 2013-05-28
• Subjects: Diabetes -- Periodicals; 618.3646005
• DOI: 10.1111/1753-0407.12024
• Languages: English
• ISSNs: 1753-0393

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <p>Based on increasing evidence from animal and human studies, vitamin D deficiency is now regarded as a potential risk factor for Type 2 diabetes mellitus (T2DM). Vitamin D is involved in the pathogenesis of pancreatic <italic>β</italic>‐cell dysfunction, insulin resistance, and systemic inflammation, conditions that contribute to the development of T2DM. Vitamin D can affect the progress of this disease directly through the activation of its own receptor, and indirectly via the regulation of calcium homeostasis. Observational studies have revealed the association between vitamin D deficiency and incident T2DM. More double‐blind randomized control studies that investigate the effects of vitamin D supplementation on insulin sensitivity, insulin secretion, and the occurrence of T2DM are needed.</p> </abstract>