A calibration‐based approach to real‐time in vivo monitoring of pyruvate C1 and C2 polarization using the JCC spectral asymmetry. (2nd April 2013)

• Record Type: Journal Article
• Authors: Lau, Justin Y. C.; Chen, Albert P.; Gu, Yi‐Ping; Cunningham, Charles H.
• Is Part Of: NMR in biomedicine. Volume 26:Number 10(2013:Oct.)
• Page Start: 1233
• Page End: 1241
• Publication Date: 2013-04-02
• Subjects: Nuclear magnetic resonance -- Periodicals; Magnetic Resonance Spectroscopy -- Periodicals; 574
• DOI: 10.1002/nbm.2942
• Languages: English
• ISSNs: 0952-3480

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>A calibration‐based technique for real‐time measurement of pyruvate polarization by partial integral analysis of the doublet from the neighbouring <italic>J</italic>‐coupled carbon is presented. <italic>In vitro</italic> calibration data relating the C₂ and C₁ asymmetries to the instantaneous C₁ and C₂ polarizations, respectively, were acquired in blood. The feasibility of using the <italic>in vitro</italic> calibration data to determine the instantaneous <italic>in vivo</italic> C₁ and C₂ polarizations was demonstrated in the analysis of rat kidney and pig heart spectral data. An approach for incorporating this technique into <italic>in vivo</italic> protocols is proposed. Copyright © 2013 John Wiley &amp; Sons, Ltd.</p> </abstract>