High‐Level Gait Disorder: Associations with Specific White Matter Changes Observed on Advanced Diffusion Imaging. Issue 1 (28th August 2012)

• Record Type: Journal Article
• Authors: Kafri, Michal; Sasson, Efrat; Assaf, Yaniv; Balash, Yaacov; Aiznstein, Orna; Hausdorff, Jeffrey M.; Giladi, Nir
• Is Part Of: Journal of neuroimaging. Volume 23:Issue 1(2013)
• Page Start: 39
• Page End: 46
• Publication Date: 2012-08-28
• Subjects: Diagnostic imaging -- Periodicals; Nervous system -- Diseases -- Diagnosis -- Periodicals; Imagerie pour le diagnostic -- Périodiques; Système nerveux -- Maladies -- Diagnostic -- Périodiques; Imagerie médicale; Neuroimagerie; Neurologie; Système nerveux; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.804754
• DOI: 10.1111/j.1552-6569.2012.00734.x
• Languages: English
• ISSNs: 1051-2284

Abstract

<abstract abstract-type="main" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="abs1-1" sec-type="section"> <title>ABSTRACT</title> </sec> <sec id="abs1-2" sec-type="section"> <title>BACKGROUND AND PURPOSE</title> <p>High‐level gait disorder (HLGD) is a debilitating disorder causing mobility decline in the elderly. Although its clinical characteristics are well described, its anatomical and pathophysiological underpinnings are poorly understood. This study examined the anatomical distribution of white matter (WM) changes in patients with mild to moderate HLGD of the cautious/disequilibrium type, using advanced magnetic resonance imaging (MRI) methods.</p> </sec> <sec id="abs1-3" sec-type="section"> <title>METHODS</title> <p>Thirteen patients with HLGD, 9 elderly and 13 middle‐aged healthy controls were scanned using diffusion tensor imaging, Q‐space imaging, and conventional MRI. The regions of significant differences between the HLGD group and the elderly control group were defined, and the mean fractional anisotropy and displacement values of these areas were extracted.</p> </sec> <sec id="abs1-4" sec-type="section"> <title>RESULTS</title> <p>The HLGD patients had lower fractional anisotropy and higher displacement values in regions related to the motor system, including those along the corticospinal tract and the superior cerebellar peduncles, as well as in cognitive and affective‐related areas, including the anterior limbs of the internal capsule and the genu of the corpus callosum.</p> </sec> <sec id="abs1-5" sec-type="section"> <title>CONCLUSIONS</title> <p>The anatomical distribution associated with HLGD of the cautious/disequilibrium type involves WM pathways that convey motor‐related, cognitive and affective‐related functions. The underlying pathological process leading to these changes most probably includes demyelination.</p> </sec> </abstract>