Confirmation of initial antiphospholipid antibody positivity depends on the antiphospholipid antibody profile. Issue 8 (14th August 2013)

• Record Type: Journal Article
• Authors: Pengo, V.; Ruffatti, A.; Del Ross, T.; Tonello, M.; Cuffaro, S.; Hoxha, A.; Banzato, A.; Bison, E.; Denas, G.; Bracco, A.; Padayattil Jose, S.
• Is Part Of: Journal of thrombosis and haemostasis. Volume 11:Issue 8(2013)
• Page Start: 1527
• Page End: 1531
• Publication Date: 2013-08-14
• Subjects: Thrombosis -- Periodicals; Hemostasis -- Periodicals; Blood coagulation disorders -- Periodicals; 616.1
• DOI: 10.1111/jth.12264
• Languages: English
• ISSNs: 1538-7933

Abstract

<abstract abstract-type="main" id="jth12264-abs-0001"> <title>Summary</title> <sec id="jth12264-sec-0001" sec-type="section"> <title>Background</title> <p>The revised classification criteria for the antiphospholipid syndrome state that antiphospholipid (aPL) antibodies (lupus anticoagulant [LAC] and/or anticardiolipin [aCL] and/or anti‐β<sub>2</sub>‐glycoprotein I [aβ<sub>2</sub>GPI] antibodies) should be detected on two or more occasions at least 12 weeks apart. Consequently, classification of patient risk and adequacy of treatment may be deferred by 3 months.</p> </sec> <sec id="jth12264-sec-0002" sec-type="section"> <title>Objectives</title> <p>In order to early classify patient risk, we evaluated whether aPL positivity confirmation is related to aPL antibody profiles.</p> </sec> <sec id="jth12264-sec-0003" sec-type="section"> <title>Patients and Methods</title> <p>Consecutive patients referred to our center who were initially positive in one or more tests exploring the presence of aPL were tested after 3 months. During a 4‐year period, 225 patients were initially positive in one or more tests, and 161 were available for confirmation after 3 months. Patients were classified as triple‐positive (<italic>n</italic> = 54: LAC<sup>+</sup>, aCL<sup>+</sup>, aβ<sub>2</sub>GPI<sup>+</sup>, same isotype), double‐positive (<italic>n</italic> = 50: LAC<sup>–</sup>, aCL<sup>+</sup>, aβ<sub>2</sub>GPI<sup>+</sup>, same isotype) and single‐positive (<italic>n</italic> = 53: LAC or aCL or aβ<sub>2</sub>GPI antibodies as the sole positive test).</p> </sec> <sec id="jth12264-sec-0004" sec-type="section"> <title>Results</title> <p>Among subjects with triple positivity at initial testing, 98% (53 of 54) had their aPL profile confirmed after 12 weeks. The double‐positive and single‐positive groups had data confirmed in 42 of 50 (84%) and 23 of 57 (40%) subjects, respectively.</p> </sec> <sec id="jth12264-sec-0005" sec-type="section"> <title>Conclusions</title> <p>Our results show that high‐risk subjects with triple‐positive aPL profiles are identified early, at the time of the initial screening tests.</p> </sec> </abstract>