Association between glucose transporter 1 rs841853 polymorphism and type 2 diabetes mellitus risk may be population specific (葡萄糖转移酶1的rs841853基因多态性与2型糖尿发生风险的关系可能具有人群特异性). (29th May 2013)

• Record Type: Journal Article
• Authors: Du, Bing; Liu, Shengmao; Cui, Chengji; Wang, Songyan; Cui, Wenpeng
• Is Part Of: Journal of diabetes. Volume 5:Number 3(2013:Jul.)
• Page Start: 291
• Page End: 299
• Publication Date: 2013-05-29
• Subjects: Diabetes -- Periodicals; 618.3646005
• DOI: 10.1111/1753-0407.12042
• Languages: English
• ISSNs: 1753-0393

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="jdb12042-sec-0001" sec-type="section"> <title>Background</title> <p>So far, studies on the association between the glucose transporter 1 (<italic>GLUT1</italic>) rs841853 polymorphism and type 2 diabetes mellitus (T2DM) risk have generated considerable controversy. The present study was performed to clarify the association of this genetic variation with T2DM.</p> </sec> <sec id="jdb12042-sec-0002" sec-type="section"> <title>Methods</title> <p>A comprehensive literature search of electronic databases was conducted to obtain articles focused on the relationship between the <italic>GLUT1</italic> rs841853 polymorphism and T2DM, followed by a systemic meta‐analysis.</p> </sec> <sec id="jdb12042-sec-0003" sec-type="section"> <title>Results</title> <p>Fourteen articles and 19 individual studies were included for analysis. Main analyses revealed extreme heterogeneity and random effect pooled odds ratios (OR) were weakly significant in allele contrast (OR 1.28; 95% confidence interval [CI] 1.01, 1.63; <italic>P</italic> = 0.04) and dominant model (OR 1.52; 95% CI 1.19, 1.94; <italic>P</italic> = 0.0008) for T allele. Subgroup analyses for Caucasians showed marginal positive results in the dominant model. However, analyses for Asians yielded an obvious relationship to T2DM risk in all genetic models. Interestingly, T allele even seemed to be a protective factor against the development of T2DM in Blacks in allele contrast. Sensitivity analyses did not alter materially for most comparisons and no publication bias was found in this meta‐analysis.</p> </sec> <sec id="jdb12042-sec-0004" sec-type="section"> <title>Conclusions</title> <p>The results of the present meta‐analysis provide evidence that the <italic>GLUT1</italic> rs841853 polymorphism may confer increased susceptibility to T2DM in Asians. However, there is no currently available strong evidence supporting the association between this genetic variation and T2DM in Caucasians, Blacks, or the overall population.</p> </sec> </abstract>