Diagnostic accuracy of faecal immunochemical test for screening individuals with a family history of colorectal cancer. Issue 7 (20th August 2013)

• Record Type: Journal Article
• Authors: Ng, S. C.; Ching, J. Y. L.; Chan, V.; Wong, M. C. S.; Suen, B. Y.; Hirai, H. W.; Lam, T. Y. T.; W Lau, J. Y.; Ng, S. S. M.; Wu, J. C. Y.; Chan, F. K. L.; Sung, J. J. Y.
• Is Part Of: Alimentary pharmacology & therapeutics. Volume 38:Issue 7(2013)
• Page Start: 835
• Page End: 841
• Publication Date: 2013-08-20
• Subjects: Digestive organs -- Diseases -- Treatment -- Periodicals; Digestive organs -- Effect of drugs on -- Periodicals; Gastrointestinal system -- Diseases -- Treatment -- Periodicals; Gastrointestinal system -- Effect of drugs on -- Periodicals; 615.73
• DOI: 10.1111/apt.12446
• Languages: English
• ISSNs: 0269-2813

Abstract

<abstract abstract-type="main" id="apt12446-abs-0001"> <title>Summary</title> <sec id="apt12446-sec-0001" sec-type="section"> <title>Background</title> <p>The role of a faecal immunochemical test (FIT) in screening individuals with a positive family history of colorectal cancer (CRC) is not clear.</p> </sec> <sec id="apt12446-sec-0002" sec-type="section"> <title>Aim</title> <p>To assess the diagnostic accuracy of FIT using colonoscopy findings as the gold standard in identifying colorectal neoplasms.</p> </sec> <sec id="apt12446-sec-0003" sec-type="section"> <title>Methods</title> <p>We analysed data from 4539 asymptomatic subjects aged 50–70 years who had both colonoscopy and FIT (Hemosure; W.H.P.M., Inc, El Monte, CA, USA) at our bowel cancer screening centre between 2008 and 2012. A total of 572 subjects (12.6%) had a family history of CRC. Our primary outcome was the sensitivity of FIT in detecting advanced neoplasms and cancers in subjects with a family history of CRC. A family history of CRC was defined as any first‐degree relative with a history of CRC.</p> </sec> <sec id="apt12446-sec-0004" sec-type="section"> <title>Results</title> <p>Among 572 subjects with a family history of CRC, adenoma, advanced neoplasm and cancer were found at screening colonoscopy in 29.4%, 6.5% and 0.7% individuals, respectively. The sensitivity of FIT in detecting adenoma, advanced neoplasm and cancer was 9.5% [95% confidence interval (CI), 5.7–15.3], 35.1% (95% CI, 20.7–52.6) and 25.0% (95% CI, 1.3–78.1), respectively. Among FIT‐negative subjects who have a family history of CRC, adenoma was found in 152 (29.6%), advanced neoplasm in 24 (4.7%) and cancer in 3 (0.6%) individuals.</p> </sec> <sec id="apt12446-sec-0005" sec-type="section"> <title>Conclusion</title> <p>Compared with colonoscopy, FIT is more likely to miss advanced neoplasms or cancers in individuals with a family history of CRC.</p> </sec> </abstract>