Venous thromboembolism does not share strong familial susceptibility with pre‐eclampsia/eclampsia: a nationwide family study in Sweden. Issue 10 (21st March 2013)

• Record Type: Journal Article
• Authors: Zöller, B; Li, X; Sundquist, J; Sundquist, K
• Is Part Of: BJOG. Volume 120:Issue 10(2013:Oct.)
• Page Start: 1200
• Page End: 1206
• Publication Date: 2013-03-21
• Subjects: Obstetrics -- Periodicals; Gynecology -- Periodicals; 618
• DOI: 10.1111/1471-0528.12216
• Languages: English
• ISSNs: 1470-0328

Abstract

<abstract abstract-type="main" id="bjo12216-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="bjo12216-sec-0001" sec-type="section"> <title>Objective</title> <p>Genetic variants associated with venous thromboembolism (VTE) have been suggested to be involved in the pathogenesis of pre‐eclampsia/eclampsia (PEC/EC). This nationwide study aimed to determine whether VTE shares familial susceptibility with PEC/EC.</p> </sec> <sec id="bjo12216-sec-0002" sec-type="section"> <title>Design</title> <p>Population‐based cohort study.</p> </sec> <sec id="bjo12216-sec-0003" sec-type="section"> <title>Setting</title> <p>Sweden.</p> </sec> <sec id="bjo12216-sec-0004" sec-type="section"> <title>Sample</title> <p>A total of 941 841 Swedish women delivering their first child between 1987 and 2008.</p> </sec> <sec id="bjo12216-sec-0005" sec-type="section"> <title>Methods</title> <p>Data from the Swedish Multigeneration Register were linked to the Swedish Hospital Discharge Register. The risk of PEC/EC was determined in primiparous women with a family history of VTE (in parents and/or siblings), compared with primiparous women without a family history of VTE. Odds ratios (ORs) were calculated by logistic regression.</p> </sec> <sec id="bjo12216-sec-0006" sec-type="section"> <title>Main outcome measure</title> <p>PEC/EC in first pregnancy.</p> </sec> <sec id="bjo12216-sec-0007" sec-type="section"> <title>Results</title> <p>In total, 43 621 women had PEC/EC in association with their first pregnancy. The OR for PEC/EC in women with a family history of VTE was 1.06 (95% CI 1.01–1.11); however, a family history of VTE was associated with higher odds of PEC/EC among women with previous hypertension (OR 1.38, 95% CI 1.25–1.52).</p> </sec> <sec id="bjo12216-sec-0008" sec-type="section"> <title>Conclusion</title> <p>A family history of VTE is weakly associated with PEC/EC risk, and is not clinically useful for the prediction of PEC/EC. The results of the present study suggest that it is unlikely that strong disease‐causing mutations shared by VTE and PEC/EC are common in the Swedish population. The novel association between family history and PEC/EC among the subgroup with previous hypertension needs further confirmation in future studies.</p> </sec> </abstract>