Adhesion and biologic behavior of human periodontal fibroblast cells to resin ionomer Geristore: a comparative analysis. Issue 5 (6th November 2012)

• Record Type: Journal Article
• Authors: Gupta, Saurabh Kumar; Saxena, Payal; Pant, Vandana Aditya; Pant, Aditya Bhushan
• Is Part Of: Dental traumatology. Volume 29:Issue 5(2013:Oct.)
• Page Start: 389
• Page End: 393
• Publication Date: 2012-11-06
• Subjects: Teeth -- Wounds and injuries -- Periodicals; Dentistry, Operative -- Periodicals; Traumatology -- Periodicals; Endodontics -- Periodicals; 617.6
• DOI: 10.1111/edt.12016
• Languages: English
• ISSNs: 1600-4469

Abstract

<abstract abstract-type="main" xml:lang="en" id="edt12016-abs-0001"> <title>Abstract</title> <sec id="edt12016-sec-0001" sec-type="section"> <title>Aim</title> <p>The resin ionomer Geristore, originally designed for restorative procedures, has been used extensively in treating subgingival defects (such as root resorption and perforations) and as a retrofilling material. The purpose of this study was to evaluate the cell adhesion as well as <italic>in vitro</italic> biocompatibility of human periodontal fibroblast cells with resin ionomer Geristore in comparison with mineral trioxide aggregate (MTA) and glass ionomer cement (GIC).</p> </sec> <sec id="edt12016-sec-0002" sec-type="section"> <title>Material and method</title> <p>Adhesion, growth, and morphology of human periodontal fibroblasts over test materials were evaluated by scanning electron microscopy (SEM). Biocompatibility was assessed by 3‐(4, 5‐dimethylthiazol‐2‐yl)‐2, 5‐diphenyltetrazolium bromide salt (MTT) assay.</p> </sec> <sec id="edt12016-sec-0003" sec-type="section"> <title>Results</title> <p>Compared to glass coverslips, cells grew and spread qualitatively better over the surface of Geristore in comparison with the other test materials. <italic>In vitro</italic> interpretation indicates that Geristore is significantly less cytotoxic to human periodontal ligament cells. Results of statistical analysis revealed that material extracts had significant effect on cell proliferation at both 24 h (<italic>F</italic> = 547.62, <italic>P </italic>< 0.05) and at 48 h (<italic>F</italic> = 6048.18, <italic>P </italic>< 0.05).</p> </sec> <sec id="edt12016-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Our study supports that Geristore has enhanced biologic behavior to human periodontal ligament cells and superior biocompatibility in comparison with MTA and GIC, so it can be suggested as a material of choice in root resorption, perforations, and root‐end filling.</p> </sec> </abstract>