Goodness‐of‐fit test for proportional subdistribution hazards model. (28th April 2013)

• Record Type: Journal Article
• Authors: Zhou, Bingqing; Fine, Jason; Laird, Glen
• Is Part Of: Statistics in medicine. Volume 32:Number 22(2013)
• Page Start: 3804
• Page End: 3811
• Publication Date: 2013-04-28
• Subjects: Medical statistics -- Periodicals; Statistique médicale -- Périodiques; Statistiques médicales -- Périodiques; 610.727
• DOI: 10.1002/sim.5815
• Languages: English
• ISSNs: 0277-6715

Abstract

<abstract abstract-type="main" id="sim5815-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p id="sim5815-para-0001">This paper concerns using modified weighted Schoenfeld residuals to test the proportionality of subdistribution hazards for the Fine–Gray model, similar to the tests proposed by Grambsch and Therneau for independently censored data. We develop a score test for the time‐varying coefficients based on the modified Schoenfeld residuals derived assuming a certain form of non‐proportionality. The methods perform well in simulations and a real data analysis of breast cancer data, where the treatment effect exhibits non‐proportional hazards. Copyright © 2013 John Wiley &amp; Sons, Ltd.</p> </abstract>