Ectopic fat and adipokines in metabolically benign overweight/obese women: The kronos early estrogen prevention study. (13th May 2013)

• Record Type: Journal Article
• Authors: Ogorodnikova, Alexandra D.; Khan, Unab I.; McGinn, Aileen P.; Zeb, Irfan; Budoff, Matthew J.; Harman, S.M.; Miller, Virginia M.; Brinton, Eliot A.; Manson, JoAnn E.; Hodis, Howard N.; Merriam, George R.; Cedars, Marcelle I.; Taylor, Hugh S.; Naftolin, Frederick; Lobo, Rogerio A.; Santoro, Nanette; Wildman, Rachel P.
• Is Part Of: Obesity. Volume 21:Number 8(2013:Aug.)
• Page Start: 1726
• Page End: 1733
• Publication Date: 2013-05-13
• Subjects: Obesity -- Periodicals; 616.398005
• DOI: 10.1002/oby.20200
• Languages: English
• ISSNs: 1930-7381

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="oby20200-sec-0001" sec-type="section"> <title>Objective</title> <p>It is unclear why despite a comparable cardiometabolic risk profile, "metabolically benign" overweight/obese individuals show an elevated risk of cardiovascular disease compared to normal weight individuals.</p> </sec> <sec id="oby20200-sec-0002" sec-type="section"> <title>Design and Methods</title> <p>In cross‐sectional analyses, we compared levels of ectopic fat (epicardial, pericardial, and hepatic fat) and adipokines (leptin, soluble leptin receptor, and high molecular weight [HMW] adiponectin) among metabolically benign (MBO) and at‐risk overweight/obese (ARO), and metabolically benign normal weight (MBNW) women, screened for the Kronos Early Estrogen Prevention Study. We defined "metabolically benign" with ≤ 1, and "at‐risk" with ≥2 components of the metabolic syndrome.</p> </sec> <sec id="oby20200-sec-0003" sec-type="section"> <title>Results</title> <p>Compared to MBO women, ARO women had significantly elevated odds of being in the top tertile of epicardial fat (OR: 1.76, 95% CI: 1.04‐2.99), hepatic fat (OR: 1.90, 95% CI:1.12‐3.24) and leptin (OR: 2.15, 95% CI: 1.23‐3.76), and the bottom tertile of HMW‐adiponectin (OR: 2.90, 95% CI: 1.62‐5.19). Compared to MBNW women, MBO women had significantly higher odds of being in the top tertile of epicardial fat (OR: 5.17, 95% CI: 3.22‐8.29), pericardial fat (OR: 9.27, 95% CI: 5.52‐15.56) and hepatic fat (OR: 2.72, 95% CI: 1.77‐4.19) and the bottom tertile of HMW adiponectin levels (OR: 2.51, 95% CI: 1.60‐3.94).</p> </sec> <sec id="oby20200-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Levels of ectopic fat and the adverse adipokine profile increase on a continuum of BMI, suggesting that the metabolically benign phenotype may be a transient state.</p> </sec> </abstract>