New surface hydroxylated and internally quaternised poly(propylene imine) dendrimers as efficient biocompatible drug carriers of norfloxacin. (October 2013)

• Record Type: Journal Article
• Authors: Murugan, Egambaram; Geetha Rani, DP; Srinivasan, K; Muthumary, J
• Is Part Of: Expert opinion on drug delivery. Volume 10:Number 10(2013:Oct.)
• Page Start: 1319
• Page End: 1334
• Publication Date: 2013-10
• Subjects: Drug delivery devices -- Periodicals; Drug delivery systems -- Periodicals; 615.605
• DOI: 10.1517/17425247.2013.801957
• Languages: English
• ISSNs: 1742-5247

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold> <italic>Objectives:</italic> </bold> This study intended to describe the development of two novel, biocompatible and potential surface hydroxylated quaternary ammonium chloride based poly(propylene imine) (PPI) dendrimers for effective delivery of the drug Norfloxacin (NFN).</p> <p> <bold> <italic>Methods:</italic> </bold> The synthetic pathway involved the hydroxylation and methylation of generation 2 and 3 PPI dendrimers and thus produced surface hydroxylated and internally quaternised PPI dendrimers viz., QPPI-OH (G2) and QPPI-OH (G3), respectively. The potential of these dendrimers were examined as drug carrier for NFN, by carrying out solubility, <italic>in vitro</italic> release, cytotoxicity and anti-bacterial studies.</p> <p> <bold> <italic>Results:</italic> </bold> It was observed that the QPPI-OH (G2)/QPPI-OH (G3) dendrimers have excellent solubilising potential/drug loading abilities of NFN in aqueous medium and can also sustain delivery of NFN. The effective complexation of NFN with QPPI-OH (G2) and QPPI-OH (G3) increased the solubility of NFN and thus elevates the NFN drug from Class 4 to Class 3 (according to BCS). These dendrimers increase the biocompatibility and increase the tolerance concentration during drug–dendrimer formulations. Anti-bacterial studies showed that the efficacy of the drug was increased in the presence of dendrimer carriers.</p> <p> <bold> <italic>Conclusions:</italic> </bold> These results indicate that the QPPI-OH (G2) and QPPI-OH (G3) dendrimers might be considered as potential biocompatible drug carriers of fluoroquinolines under suitable conditions.</p> </abstract>