Association between Three Genetic Variants of the Perilipin Gene (PLIN) and Glucose Metabolism: Results from a Replication Study among Chinese Adults and a Meta-Analysis. (November 2013)

• Record Type: Journal Article
• Authors: Yu, Dahai; Li, Chunyang; Xie, Jing; Xu, Guoheng; Li, Yanyan; Liu, Jiyan; Chen, Bing; Pan, Jingjing; Shen, Minghui; Yang, Liming; Hu, Dongsheng
• Is Part Of: Endocrine research. Volume 38:Number 4(2013:Nov.)
• Page Start: 263
• Page End: 279
• Publication Date: 2013-11
• Subjects: Endocrinology, Experimental -- Periodicals; Endocrinology -- Periodicals; Endocrinology -- Periodicals; Research -- Periodicals; 616.4
• DOI: 10.3109/07435800.2013.778864
• Languages: English
• ISSNs: 0743-5800

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p> <italic>Objective</italic>. This study was aimed to replicate the associations between three Perilipin Gene (<italic>PLIN</italic>) variants (rs894160, rs1052700, and rs2304796) and diabetes risks and to evaluate the overall effects of these variants on diabetes risk and obesity risk. <italic>Methods</italic>. We conducted a cross-sectional study among 993 Chinese Han adults. We also made a meta-analysis to estimate associations between these variants and diabetes risk and obesity risk. <italic>Results</italic>. In the sample of all participants, all three single-nucleotide polymorphisms (SNPs) were not significantly associated with diabetes risks. The <italic>PLIN</italic> polymorphisms significantly interacted with central obesity in relation to diabetes risk (<italic>P</italic> for interaction = 0.036, 0.033, and 0.042 for rs1052700, rs894160, and rs2304796, respectively). In those with allele <italic>T</italic> of rs1052700 or allele <italic>A</italic> of rs894160, fasting glucose concentration and diabetes risk increased significantly with the increment of waist circumference. Only association between rs894160 and obesity risk was available for meta-analysis. The meta-analysis indicated the overall estimation of obesity risk for rs894160 was 0.97 (0.78, 1.16) among participants with allele <italic>A</italic> versus people with genotype <italic>GG</italic> and 1.46 (0.99, 1.93) among those with genotype <italic>AA </italic>versus<italic> allele G carriers. Conclusion. </italic>Chinese adults with high waist circumference may have a high risk of diabetes, especially among those with allele <italic>T</italic> in rs1052700 or with allele <italic>A</italic> in rs894160. People with genotype <italic>AA</italic> (rs894160) may have a high risk of obesity.</p> </abstract>