SLC41A1 is the only magnesium responsive gene significantly overexpressed in placentas of preeclamptic women†. (November 2013)

• Record Type: Journal Article
• Authors: Kolisek, Martin; Galaviz-Hernández, Carlos; Vázquez-Alaniz, Fernando; Sponder, Gerhard; Javaid, Saba; Kurth, Katharina; Nestler, Axel; Rodríguez-Moran, Martha; Verlohren, Stefan; Guerrero-Romero, Fernando; Aschenbach, Jörg Rudolf; Vormann, Jürgen
• Is Part Of: Hypertension in pregnancy. Volume 32:Number 4(2013)
• Page Start: 378
• Page End: 389
• Publication Date: 2013-11
• Subjects: Hypertension in pregnancy -- Periodicals; Pregnancy -- Complications -- Periodicals; 618.3261
• DOI: 10.3109/10641955.2013.810237
• Languages: English
• ISSNs: 1064-1955

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p> <italic>Objective</italic>: To examine expression profile of magnesium responsive genes (<italic>MRGs</italic>) in placentas of normoevolutive and preeclamptic women. <italic>Methods</italic>: The expression profiles of <italic>MRGs</italic> were determined in placentas of normoevolutive (<italic>N</italic> = 26) and preeclamptic (<italic>N</italic> = 25) women by RT-qPCR. <italic>Results</italic>: Among all tested <italic>MRGs</italic> (9) only <italic>SLC41A1</italic> (encoding for Na⁺/Mg²⁺ exchanger) was significantly overexpressed in ∼54.2% of preeclamptic (<italic>n</italic> = 24) and in ∼9.5% of normoevolutive (<italic>n</italic> = 21) specimens. On average, <italic>SLC41A1</italic> was overexpressed sixfold in the preeclamptic group. Presence of SLC41A1 in placentas was confirmed by Western blot analysis. <italic>Conclusion. SLC41A1</italic> is significantly overexpressed in nearly 55% of preeclamptic placentas. This may indicate a direct contribution of changed Mg homeostasis in the development of preeclampsia.</p> </abstract>