BMP4 is Involved in the Chemoresistance of Myeloid Leukemia Cells Through Regulating Autophagy–Apoptosis Balance. (1st October 2013)

• Record Type: Journal Article
• Authors: Zhao, Xielan; Liu, Juan; Peng, Minyuan; Liu, Jing; Chen, Fangping
• Is Part Of: Cancer investigation. Volume 31:Number 8(2013)
• Page Start: 555
• Page End: 562
• Publication Date: 2013-10-01
• Subjects: Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.3109/07357907.2013.834925
• Languages: English
• ISSNs: 0735-7907

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p>This study showed that silencing BMP4 expression significantly activated caspase-2, 3, and 9, while decreasing Matrigel colony formation in Cytarabine (Ara-C)-treated leukemia HL-60 cells. In contrast, Ara-C significantly upregulated Atg5 and Beclin-1 expression, the ratio of LC3-II/LC3-I, and CDK1 and cyclin B1 expression in leukemia cells expressing BMP4. BafA significantly sensitized the apoptotic effect of Ara-C in leukemia cells. Injection of Ara-C significantly inhibited tumor growth in mice inoculated with leukemia cells with BMP4 silenced. In conclusion, BMP4 plays a crucial role in the chemoresistance of leukemia cells through the activation of autophagy and subsequent inhibition of apoptosis.</p> </abstract>