Nanoparticles laden in situ gel of levofloxacin for enhanced ocular retention. (September 2013)

• Record Type: Journal Article
• Authors: Gupta, Himanshu; Aqil, M.; Khar, R. K.; Ali, Asgar; Bhatnagar, Aseem; Mittal, Gaurav
• Is Part Of: Drug delivery. Volume 20:Number 7(2013:Oct.)
• Page Start: 306
• Page End: 309
• Publication Date: 2013-09
• Subjects: Drug delivery systems -- Periodicals; Drug targeting -- Periodicals; 615.05
• DOI: 10.3109/10717544.2013.838712
• Languages: English
• ISSNs: 1071-7544

Abstract

<abstract> <title>Abstract</title> <p>Availability of proper concentration of medicament on to the corneal surface is a challenging task. Many novel formulations, i.e. hydrogels, nanoparticles, ocuserts, etc. had been tested to improve ocular bioavailability, out of which our group found, <italic>in situ</italic> gel and polymeric nanoparticle are the most interesting approach to achieve ocular retention. We found that <italic>in situ</italic> gel stay only for 12 h and poly(lactic-co-glycolic acid (PLGA) nanoparticles are non mucoadhesive in nature so we try to combine both these formulations and termed it as "Nanoparticle laden <italic>in situ</italic> gel". Here we prepare nanoparticle laden <italic>in situ</italic> gel containing levofloxacin encapsulated PLGA nanoparticle, incorporated in chitosan <italic>in situ</italic> gel and evaluated its ocular retention by gamma scintigraphy in rabbits. The observations of acquired gamma camera images showed good retention over the entire precorneal area. From static and dynamic gamma scintigraphy evaluation, we can be interpret that developed nanoparticle laden <italic>in situ</italic> gel formulation cleared at a very slow rate and remained at corneal surface for longer duration than marketed formulation, <italic>in situ</italic> gel and nanosuspension alone.</p> </abstract>