Effect of periodontal treatment on glycemic control of patients with diabetes: A systematic review and meta‐analysis. Issue 5 (18th April 2013)

• Record Type: Journal Article
• Authors: Corbella, Stefano; Francetti, Luca; Taschieri, Silvio; De, Francesca; Fabbro, Massimo Del
• Is Part Of: Journal of diabetes investigation. Volume 4:Issue 5(2013:Oct.)
• Page Start: 502
• Page End: 509
• Publication Date: 2013-04-18
• Subjects: Diabetes -- Periodicals; Diabetes -- Research -- Periodicals; Diabetes Mellitus -- Periodicals; 616.462005
• DOI: 10.1111/jdi.12088
• Languages: English
• ISSNs: 2040-1116

Abstract

<abstract abstract-type="main" xml:lang="en" id="jdi12088-abs-0001"> <title>Abstract</title> <sec id="jdi12088-sec-0001" sec-type="section"> <title>Aims/Introduction</title> <p>The aim of the present study was to investigate whether non‐surgical periodontal treatment reduces glycated hemoglobin (HbA<sub>1c</sub>) and fasting plasma glucose (FPG) levels in diabetic patients.</p> </sec> <sec id="jdi12088-sec-0002" sec-type="section"> <title>Materials and Methods</title> <p>An electronic search was carried out on MEDLINE (through PubMed interface), EMBASE and the Cochrane Central Register of Controlled Trials. Randomized controlled trials with a minimum of 3 months follow up were included. The risk of bias was assessed for each study. A meta‐analysis was carried out to evaluate the effect of non‐surgical periodontal treatment on HbA<sub>1c</sub> and FPG levels. The effect of the adjunctive use of antimicrobials was also assessed.</p> </sec> <sec id="jdi12088-sec-0003" sec-type="section"> <title>Results</title> <p>A total of 15 studies were included. A reduction of −0.38% (95% confidence interval [CI] −0.23 to −0.53) after 3–4 months (<italic>P</italic> < 0.001) and of −0.31% (95% CI 0.11 to −0.74) after 6 months (<italic>P</italic> = 0.15) of follow‐up was found for HbA<sub>1c</sub>, favoring the treatment group. Similarly, in treated patients, a significantly greater decrease in FPG was observed in respect to control participants. Such difference amounted to −9.01 mg/dL (95% CI −2.24 to −15.78) after 3–4 months (<italic>P</italic> = 0.009) and −13.62 mg/dL (95% CI 0.45 to −27.69) after 6 months (<italic>P</italic> = 0.06) from treatment, respectively. In participants treated with adjunctive antimicrobials, a non‐significant increase of HbA<sub>1c</sub> was observed 3 months after treatment, whereas FPG decreased by 0.27 mg/dL (95% CI 39.56 to −40.11; <italic>P</italic> = 0.99).</p> </sec> <sec id="jdi12088-sec-0004" sec-type="section"> <title>Conclusions</title> <p>The meta‐analysis showed that non‐surgical periodontal treatment improves metabolic control in patients with both periodontitis and diabetes.</p> </sec> </abstract>