Evaluation of MYC status in oral lichen planus in patients with progression to oral squamous cell carcinoma. (8th July 2013)

• Record Type: Journal Article
• Authors: Segura, S.; Rozas‐Muñoz, E.; Toll, A.; Martín‐Ezquerra, G.; Masferrer, E.; Espinet, B.; Rodriguez, M.; Baró, T.; Barranco, C.; Pujol, R.M.
• Is Part Of: British journal of dermatology. Volume 169:Number 1(2013:Jul.)
• Page Start: 106
• Page End: 114
• Publication Date: 2013-07-08
• Subjects: Dermatology -- Periodicals; Skin -- Diseases -- Periodicals; 616.5
• DOI: 10.1111/bjd.12303
• Languages: English
• ISSNs: 0007-0963

Abstract

<abstract abstract-type="short" xml:lang="en" id="bjd12303-abs-0002"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>What's already known about this topic?</bold> </p> <p> <list id="bjd12303-list-0001" list-type="bullet"> <list-item> <p>Malignant transformation of oral lichen planus (OLP) to oral squamous cell carcinoma (OSCC) is controversial.</p> </list-item> <list-item> <p>Clinical and histological features of OLP lesions have limited prognostic value.</p> </list-item> </list> </p> <p> <bold>What does this study add?</bold> </p> <p> <list id="bjd12303-list-0002" list-type="bullet"> <list-item> <p>OLP lesions from patients with progression to OSCC show <italic>MYC</italic> gains and C‐MYC overexpression, not present in OLP lesions from patients without evolution to OSCC.</p> </list-item> <list-item> <p>Determining MYC status on some OLP lesions may predict a subgroup of patients with a higher risk of progression to OSCC.</p> </list-item> </list> </p> </abstract>