Is thyrotropin‐releasing hormone a novel neuroendocrine modulator of keratin expression in human skin?. (8th July 2013)

• Record Type: Journal Article
• Authors: Ramot, Y.; Zhang, G.; Bíró, T.; Langbein, L.; Paus, R.
• Is Part Of: British journal of dermatology. Volume 169:Number 1(2013:Jul.)
• Page Start: 146
• Page End: 151
• Publication Date: 2013-07-08
• Subjects: Dermatology -- Periodicals; Skin -- Diseases -- Periodicals; 616.5
• DOI: 10.1111/bjd.12264
• Languages: English
• ISSNs: 0007-0963

Abstract

<abstract abstract-type="short" xml:lang="en" id="bjd12264-abs-0002"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>What's already known about this topic?</bold> </p> <p> <list id="bjd12264-list-0001" list-type="bullet"> <list-item> <p>Although keratins are one of the major structural components of the hair fibre and skin epithelium, their hormonal regulation is still relatively ill understood.</p> </list-item> <list-item> <p>Because the role of neuropeptide hormones in the control of keratin expression remains largely obscure, we have followed up preliminary microarray‐based evidence which had suggested that thyrotropin‐releasing hormone (TRH) may modulate keratin expression in human hair follicles.</p> </list-item> </list> </p> <p> <bold>What does this study add?</bold> </p> <p> <list id="bjd12264-list-0002" list-type="bullet"> <list-item> <p>The current study provides evidence that the neuropeptide hormone TRH can act as a novel neuroendocrine modulator of the expression of human hair and epithelial keratins <italic>in situ</italic>; this identifies the neuroendocrine regulation of keratin expression as an exciting new research frontier in skin biology and dermatology.</p> </list-item> <list-item> <p>Together with the recently identified stimulatory activity of TRH on mitochondrial activity, hair pigmentation and hair growth in human skin, the potent keratin expression‐modulating effects of TRH revealed here may serve as a basis for novel therapeutic strategies that recruit neurohormones to modulate keratin expression in human skin and its appendages.</p> </list-item> </list> </p> </abstract>