Significant association between asthma risk and the GSTM1 and GSTT1 deletion polymorphisms: An updated meta‐analysis of case–control studies. Issue 5 (21st June 2013)

• Record Type: Journal Article
• Authors: Liang, Siqiao; Wei, Xuan; Gong, Chen; Wei, Jinmei; Chen, Zhangrong; Chen, Xiaoli; Wang, Zhibo; Deng, Jingmin
• Is Part Of: Respirology. Volume 18:Issue 5(2013)
• Page Start: 774
• Page End: 783
• Publication Date: 2013-06-21
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiratory organs -- Periodicals; 612.2
• DOI: 10.1111/resp.12097
• Languages: English
• ISSNs: 1323-7799

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <p>Polymorphisms in <italic>GSTM1</italic> and <italic>GSTT1</italic> may be associated with asthma risk, yet several studies and meta‐analyses have reported inconclusive results. Therefore, an updated meta‐analysis was conducted. Literature searches were performed using the Pubmed, Embase and Web of Science databases until October 2012. Variant 'null' genotype was compared with wild‐type 'present' in the pooled data. All statistical analyses were performed using STATA 11.0. A total of 26 case–control studies were suitable for inclusion in the meta‐analysis. In the overall population, a significant association was found for both the <italic>GSTM1</italic> (odds ratio (OR) = 1.452; 95% confidence interval (CI): 1.192–1.770) and <italic>GSTT1</italic> polymorphism (OR = 1.792; 95% CI:1.293–2.483). For subgroup analysis by age, <italic>GSTM1</italic> significantly increased risk for both children (OR = 1.368; 95% CI: 1.051–1.781) and adults (OR = 1.859; 95% CI: 1.183–2.921). For <italic>GSTT1</italic>, a significant association was only found in the adult population (OR = 2.312; 95%CI: 1.204–4.439). Based on subgroup analysis by ethnicity, a significant association for <italic>GSTM1</italic> was found in Europe (OR = 1.303; 95% CI: 1.018–1.667), Africa (OR = 2.175; 95%CI: 1.560–3.031) and Latin America (OR = 2.265; 95%CI: 1.375–3.729). For <italic>GSTT1</italic>, significantly increased risk was found only for Asian (OR = 2.105; 95% CI: 1.101–4.025) and Russian (OR = 2.747; 95% CI: 1.071–7.046) populations. This meta‐analysis provides evidence that <italic>GSTM1</italic> and <italic>GSTT1</italic> polymorphisms may be risk factors for asthma.</p> </abstract>