Are human endogenous retroviruses pathogenic? An approach to testing the hypothesis. (17th July 2013)

• Record Type: Journal Article
• Authors: Young, George R.; Stoye, Jonathan P.; Kassiotis, George
• Is Part Of: BioEssays. Volume 35:Number 9(2013:Sep.)
• Page Start: 794
• Page End: 803
• Publication Date: 2013-07-17
• Subjects: Molecular biology -- Periodicals; Cytology -- Periodicals; Developmental biology -- Periodicals; 572.8
• DOI: 10.1002/bies.201300049
• Languages: English
• ISSNs: 0265-9247

Abstract

<abstract abstract-type="main" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="bies201300049-sec-0001" sec-type="section"> <p>A number of observations have led researchers to postulate that, despite being replication‐defective, human endogenous retroviruses (HERVs) may have retained the potential to cause or contribute to disease. However, mechanisms of HERV pathogenicity might differ substantially from those of modern infectious retroviruses or of the infectious precursors of HERVs. Therefore, novel pathways of HERV involvement in disease pathogenesis should be investigated. Recent technological advances in sequencing and bioinformatics are making this task increasingly feasible. The accumulating knowledge of HERV biology may also facilitate the definition and general acceptance of criteria that establish HERV pathogenicity. Here, we explore possible mechanisms whereby HERVs may cause disease and examine the evidence that either has been or should be obtained in order to decisively address the pathogenic potential of HERVs.</p> </sec> </abstract>