Postload hyperglycemia is associated with increased subclinical inflammation in patients with prediabetes. (August 2013)

• Record Type: Journal Article
• Authors: Colak, Ayfer; Akinci, Baris; Diniz, Gulden; Turkon, Hakan; Ergonen, Faruk; Yalcin, Hulya; Coker, Isil
• Is Part Of: Scandinavian journal of clinical & laboratory investigation. Volume 73:Number 5(2013)
• Page Start: 422
• Page End: 427
• Publication Date: 2013-08
• Subjects: Clinical biochemistry -- Periodicals; Physiology, Pathological -- Periodicals; Physiology, Experimental -- Periodicals; Medicine -- Research -- Periodicals; Clinical medicine -- Periodicals; 616.0072
• DOI: 10.3109/00365513.2013.798870
• Languages: English
• ISSNs: 0036-5513

Abstract

<abstract> <title>Abstract</title> <p> <bold> <italic>Background/aims</italic>.</bold> In this present study, we aimed: (i) To clarify if prediabetes is associated with subclinical inflammation independent of underlying obesity, and (ii) to evaluate the effect of postload glucose concentration on subclinical inflammation markers in a group of patients with elevated fasting glucose. <bold><italic>Material and methods</italic>.</bold> In a cohort of 165 patients with newly detected fasting hyperglycemia, according to 75 g oral glucose tolerance test (OGTT), subjects were classified either as newly diagnosed type 2 diabetes (diabetes group, <italic>n</italic> = 40), impaired fasting glucose (IFG) plus impaired glucose tolerance (IGT) (IFG/IGT group, <italic>n</italic> = 42) or IFG only (IFG group, <italic>n</italic> = 83). A control group (<italic>n</italic> = 47) consisted of age- and body mass index (BMI)-matched healthy subjects with a normal OGTT. Circulating concentrations of lipids, insulin, interleukin-6 (IL-6), interleukin-8 (IL-8) and high sensitive C-reactive protein (hsCRP) were measured. HOMA index was calculated. <bold><italic>Results</italic>.</bold> Subclinical inflammation markers were elevated in patients with diabetes and IFG/IGT compared to healthy controls and also IFG patients (diabetes vs. control: <italic>p</italic> < 0.05 for hsCRP, IL-8, and IL-6; IFG/IGT vs. control: <italic>p</italic> < 0.05 for hsCRP, and IL-6; diabetes vs. IFG: <italic>p</italic> < 0.05 for hsCRP, and IL-6; IFG/IGT vs. IFG: <italic>p</italic> < 0.05 for hsCRP, and IL-6). In multiple regression analysis, postload glucose concentration was independently associated with circulating hsCRP and IL-6 concentrations when the data was controlled for age, gender, BMI and lipid concentrations (<italic>p</italic> < 0.05 for hsCRP, and IL-6). <bold><italic>Conclusion</italic>.</bold> Our results suggest that patients with prediabetes, independent of underlying obesity, have increased concentrations of subclinical inflammation which is mostly driven by postload glucose concentrations.</p> </abstract>