Effect of interpregnancy interval on outcomes of pregnancy after recurrent pregnancy loss. (September 2013)

• Record Type: Journal Article
• Authors: Bentolila, Yaara; Ratzon, Ronit; Shoham-Vardi, Ilana; Serjienko, Ruslan; Mazor, Moshe; Bashiri, Asher
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 26:Number 14(2013)
• Page Start: 1459
• Page End: 1464
• Publication Date: 2013-09
• Subjects: Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• DOI: 10.3109/14767058.2013.784264
• Languages: English
• ISSNs: 1476-7058

Abstract

<abstract> <title>Abstract</title> <p> <italic>Objective</italic>: To examine the effect of interpregnancy interval (IPI) on outcomes of pregnancy after recurrent pregnancy loss (RPL).</p> <p> <italic>Methods</italic>: A retrospective cohort study including 325 patients treated at a RPL clinic, with two or more consecutive pregnancy losses followed by a subsequent (index) pregnancy, of whom 163 had IPI ≤ 6 months, and 212 had IPI &gt; 6 months.</p> <p> <italic>Results</italic>: Pregnancy loss rate in the index pregnancy was positively associated with increased IPI (18.6% in women with IPI ≤ 6 months, and 29.7% in women with IPI &gt; 6 months; <italic>p</italic> = 0.029). In a multivariable logistic analysis, excluding women with fertility problems, and adjusting for maternal age and ethnicity, the OR for pregnancy loss rate for IPI longer than 6 months compared to shorter IPI was 1.76 (95%CI: 0.96–3.22, <italic>p</italic> = 0.067).</p> <p> <italic>Conclusions</italic>: Our results suggest that IPI shorter than 6 months, in women with no fertility problems, is associated with lower rate of subsequent miscarriage. Further studies are needed to substantiate this finding.</p> </abstract>