Association between the MDR1 gene variant C3435T and risk of leukaemia: a meta‐analysis. (3rd June 2013)

• Record Type: Journal Article
• Authors: Zhang, B‐B.; Xuan, C.; Deng, K‐F.; Wu, N.; Lun, L‐M.
• Is Part Of: European journal of cancer care. Volume 22:Number 5(2013:Sep.)
• Page Start: 617
• Page End: 625
• Publication Date: 2013-06-03
• Subjects: Cancer -- Nursing -- Periodicals; 616.994
• DOI: 10.1111/ecc.12067
• Languages: English
• ISSNs: 0961-5423

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Although a number of genetic studies have attempted to link the multidrug resistance (<italic>MDR1</italic>) C3435T polymorphism to risk of leukaemia, the results were often inconsistent. The present study aimed at investigating the pooled association using a meta‐analysis on the published studies. 1933 cases and 2215 controls of 11 published studies in English before June 2012 were involved in the updated meta‐analysis. Furthermore, subgroup analysis was performed in different ethnic and leukaemia subtype groups. This meta‐analysis suggests that the <italic>MDR1</italic> C3435T polymorphism associate with risk of leukaemia. The effect of the variant on the expression levels and the possible functional role of the variant in leukaemia should be addressed in further studies.</p> </abstract>