Natural killer expansion, human leukocyte antigens‐E expression and CD14+ CD56+ monocytes in a myelodysplastic syndrome patient. (28th June 2013)

• Record Type: Journal Article
• Authors: Terrazzano, Giuseppe; Rubino, Valentina; Palatucci, Anna Teresa; Giovazzino, Angela; Annunziatella, Mariangela; Vitagliano, Orsola; Alfinito, Fiorella; Ruggiero, Giuseppina
• Is Part Of: European journal of haematology. Volume 91:Number 3(2013:Sep.)
• Page Start: 265
• Page End: 269
• Publication Date: 2013-06-28
• Subjects: Hematology -- Periodicals; Blood -- Diseases -- Periodicals; Blood -- Periodicals; 616.15005
• DOI: 10.1111/ejh.12152
• Languages: English
• ISSNs: 0902-4441

Abstract

<abstract abstract-type="main" id="ejh12152-abs-0001"> <title>Abstract</title> <p>Myelodysplastic syndromes (MDS) are clonal disorders characterized by ineffective hematopoiesis and possible evolution to acute leukemia. Occurrence of stem cell defects and of immune‐mediated mechanisms was evidenced as relevant for pathophysiology of MDS. Here, we described one case of MDS patient carrying CD14⁺CD56⁺ monocytes in bone marrow (BM), in the presence of a defective human leukocyte antigen (HLA)‐E expression on peripheral blood (PB) cells and of natural killer (NK) cell expansion in PB and BM. The defective HLA‐E expression and the NK expansion are proposed to be relevant for the pathogenesis of myelodysplasia in those patients showing CD14⁺CD56⁺ monocytes in BM.</p> </abstract>