Faster pharmacokinetics and increased patient acceptance of intradermal insulin delivery using a single hollow microneedle in children and adolescents with type 1 diabetes. Issue 6 (21st March 2013)

• Record Type: Journal Article
• Authors: Norman, James J; Brown, Milton R; Raviele, Nicholas A; Prausnitz, Mark R; Felner, Eric I
• Is Part Of: Pediatric diabetes. Volume 14:Issue 6(2013)
• Page Start: 459
• Page End: 465
• Publication Date: 2013-03-21
• Subjects: Diabetes in children -- Periodicals; 616.462
• DOI: 10.1111/pedi.12031
• Languages: English
• ISSNs: 1399-543X

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="pedi12031-sec-0001" sec-type="section"> <title>Objective</title> <p>In an effort to improve compliance with insulin therapy and to accelerate insulin pharmacokinetics, we tested the hypothesis that intradermal insulin delivery using a hollow microneedle causes less pain and leads to faster onset and offset of insulin pharmacokinetics in children and adolescents with type 1 diabetes (T1DM) compared with a subcutaneous, insulin pump catheter.</p> </sec> <sec id="pedi12031-sec-0002" sec-type="section"> <title>Research design and methods</title> <p>In this repeated measures study, 16 children and adolescents with T1DM received Lispro insulin by microneedle and subcutaneous administration on separate days. Subjects rated the pain of insertion and infusion using a visual analog scale. Blood specimens were collected over 4 h to determine insulin and glucose concentrations.</p> </sec> <sec id="pedi12031-sec-0003" sec-type="section"> <title>Results</title> <p>Microneedle insertion pain was significantly lower compared with insertion of the subcutaneous catheter (p = 0.005). Insulin onset time was 22 min faster (p = 0.0004) and offset time was 34 min faster (p = 0.017) after hollow microneedle delivery compared with subcutaneous delivery.</p> </sec> <sec id="pedi12031-sec-0004" sec-type="section"> <title>Conclusions</title> <p>In this study, intradermal insulin delivery using a single, hollow microneedle device resulted in less insertion pain and faster insulin onset and offset in children and adolescents with T1DM. A reduction in pain might improve compliance with insulin delivery. The faster onset and offset times of insulin action may enable closed‐loop insulin therapy.</p> </sec> </abstract>