Comparison of the Diagnostic Accuracy of Five Different Stool Antigen Tests for the Diagnosis of Helicobacter pylori Infection. Issue 5 (3rd April 2013)

• Record Type: Journal Article
• Authors: Korkmaz, Huseyin; Kesli, Recep; Karabagli, Pinar; Terzi, Yuksel
• Is Part Of: Helicobacter. Volume 18:Issue 5(2013:Oct.)
• Page Start: 384
• Page End: 391
• Publication Date: 2013-04-03
• Subjects: Helicobacter -- Periodicals; Helicobacter infections -- Periodicals; Stomach -- Diseases -- Periodicals; 616.3301405
• DOI: 10.1111/hel.12053
• Languages: English
• ISSNs: 1083-4389

Abstract

<abstract abstract-type="main" xml:lang="en" id="hel12053-abs-0001"> <title>Abstract</title> <sec id="hel12053-sec-0001" sec-type="section"> <title>Background</title> <p>Several noninvasive diagnostic tests based on the detection of Helicobacter pylori stool antigen (HpSA) have been developed. The aim of the study was to compare the diagnostic accuracy of 5 HpSA tests—2 monoclonal enzyme immunoassay tests (EIAs: the Premier Platinum HpSA Plus test and <italic>Helicobacter pylori </italic>Antigen (Hp Ag) test) and 3 rapid immunochromatographic assay (ICA) tests (the ImmunoCard STAT! HpSA test, one step HpSA test<bold>, </bold> and <italic>H. pylori</italic> fecal antigen test)—for diagnosing <italic>H. pylori</italic> infection in adult patients with dyspeptic symptoms before eradication therapy.</p> </sec> <sec id="hel12053-sec-0002" sec-type="section"> <title>Materials and Methods</title> <p>A total of 198 patients with dyspeptic symptoms were included in the study. A gastric biopsy was collected for histopathology and rapid urease testing. Stool specimens for HpSA testing were also collected. Patients were considered <italic>H. pylori</italic> positive if two invasive tests (histological and rapid urease tests) were positive.</p> </sec> <sec id="hel12053-sec-0003" sec-type="section"> <title>Results</title> <p>The sensitivity and specificity were 92.2% and 94.4%, respectively, for the Premier Platinum HpSA Plus test; 48.9% and 88.9%, respectively, for the HP Ag test; 86.7% and 88.9, respectively, for the One Step HpSA test; 68.9% and 92.6%, respectively, for the ImmunoCard STAT! HpSA test; and 78.9% and 87%, respectively, for the <italic>H. Pylori</italic> fecal antigen test.</p> </sec> <sec id="hel12053-sec-0004" sec-type="section"> <title>Conclusions</title> <p>The Premier Platinum HpSA Plus EIA test was determined to be the most accurate stool test for diagnosing <italic>H. pylori</italic> infections in adult dyspeptic patients. The currently available ICA‐based tests are fast and easy to use but provide less reliable results.</p> </sec> </abstract>