Bordetella holmesii: initial genomic analysis of an emerging opportunist. Issue 2 (26th February 2013)

• Record Type: Journal Article
• Authors: Planet, Paul J.; Narechania, Apurva; Hymes, Saul R.; Gagliardo, Christina; Huard, Richard C.; Whittier, Susan; Della‐Latta, Phyllis; Ratner, Adam J.
• Is Part Of: Pathogens and disease. Volume 67:Issue 2(2013:Mar.)
• Page Start: 132
• Page End: 135
• Publication Date: 2013-02-26
• Subjects: Medical microbiology -- Periodicals; Pathogenic microorganisms -- Periodicals; Communicable diseases -- Microbiology -- Periodicals; Communicable diseases -- Pathogenesis -- Periodicals; Host-parasite relationships -- Periodicals; Systems biology -- Periodicals; 616.904105
• DOI: 10.1111/2049-632X.12028
• Languages: English
• ISSNs: 2049-632X

Abstract

<abstract abstract-type="main" id="fim12028-abs-0001"> <title>Abstract</title> <p> <italic>Bordetella holmesii</italic> is an emerging opportunistic pathogen that causes respiratory disease in healthy individuals and invasive infections among patients lacking splenic function. We used 16S rRNA gene analysis to confirm <italic>B. holmesii</italic> as the cause of bacteremia in a child with sickle cell disease. Semiconductor‐based draft genome sequencing provided insight into <italic>B. holmesii</italic> phylogeny and potential virulence mechanisms and also identified a toluene‐4‐monoxygenase locus unique among bordetellae.</p> </abstract>