Octodon degus: A Model for the Cognitive Impairment Associated with Alzheimer's Disease. (27th May 2013)

• Record Type: Journal Article
• Authors: Tarragon, Ernesto; Lopez, Dolores; Estrada, Cristina; Ana, Gonzalez‐Cuello; Schenker, Esther; Pifferi, Fabien; Bordet, Regis; Richardson, Jill C.; Herrero, Maria Trinidad
• Is Part Of: CNS neuroscience & therapeutics. Volume 19:Number 9(2013)
• Page Start: 643
• Page End: 648
• Publication Date: 2013-05-27
• Subjects: Neuropharmacology -- Periodicals; Central nervous system -- Diseases -- Effect of drugs on -- Periodicals; 612.8
• DOI: 10.1111/cns.12125
• Languages: English
• ISSNs: 1755-5930

Abstract

<abstract abstract-type="main" id="cns12125-abs-0001"> <title>Summary</title> <p> <italic>Octodon degus</italic> (<italic>O. degus</italic>) is a diurnal rodent that spontaneously develops several physiopathological conditions, analogous in many cases to those experienced by humans. In light of this, <italic>O. degus</italic> has recently been identified as a very valuable animal model for research in several medical fields, especially those concerned with neurodegenerative diseases in which risk is associated with aging. <italic>Octodon degus</italic> spontaneously develops β‐amyloid deposits analogous to those observed in some cases of Alzheimer's disease (AD). Moreover, these deposits are thought to be the key feature for AD diagnosis, and one of the suggested causes of cell loss and cognitive deficit. This review aims to bring together information to support <italic>O. degus</italic> as a valuable model for the study of AD.</p> </abstract>