Pathogenic Yersinia DNA in Intestinal Specimens of Pediatric Patients with Crohn's Disease. (1st October 2013)

• Record Type: Journal Article
• Authors: Leu, Sarah B.; Shulman, Sarah Catherine; Steelman, Charlotte Katherine; Lamps, Laura W.; Bulut, Ozlem P.; Abramowsky, Carlos R.; Gold, Benjamin D.; Szlam, Sarah; Stockwell, Christina; Havens, Jennifer; Kolta, Soha; Shehata, Bahig M.
• Is Part Of: Fetal and pediatric pathology. Volume 32:Number 5(2013)
• Page Start: 367
• Page End: 370
• Publication Date: 2013-10-01
• Subjects: Pathology, Molecular -- Periodicals; Pediatrics -- Periodicals; Molecular biology -- Periodicals; Pediatric pathology -- Periodicals; Fetal Diseases -- pathology -- Periodicals; Infant, Newborn, Diseases -- pathology -- Periodicals; Pediatrics -- Periodicals; 618.92007
• DOI: 10.3109/15513815.2013.768744
• Languages: English
• ISSNs: 1551-3815

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p>Studies indicate a close relationship between <italic>Yersinia</italic> and Crohn's disease in adults. Our study tested 77 colonic specimens from children with Crohn's disease for the presence of <italic>Yersinia</italic> DNA using a validated polymerase chain reaction (PCR) assay. Control cases included specimens from 45 ulcerative colitis patients and 10 appendicitis patients. The presence of <italic>Yersinia</italic> in Crohn's specimens was significant compared to the control specimens (9% vs. 0%; <italic>p</italic> = 0.0055). While our study supports the medical literature, future studies are needed to determine if the relationship between Crohn's disease and <italic>Yersinia</italic> is an initiating or mediating factor in the pathogenesis of pediatric Crohn's disease.</p> </abstract>