Retinoic acids up‐regulate functional eosinophil‐driving receptor CCR3. Issue 7 (6th June 2013)

• Record Type: Journal Article
• Authors: Ueki, S.; Nishikawa, J.; Yamauchi, Y.; Konno, Y.; Tamaki, M.; Itoga, M.; Kobayashi, Y.; Takeda, M.; Moritoki, Y.; Ito, W.; Chihara, J.
• Is Part Of: Allergy. Volume 68:Issue 7(2013:Jul.)
• Page Start: 953
• Page End: 956
• Publication Date: 2013-06-06
• Subjects: Allergy -- Periodicals; 616.97
• DOI: 10.1111/all.12175
• Languages: English
• ISSNs: 0105-4538

Abstract

<abstract abstract-type="main" id="all12175-abs-0001"> <title>Abstract</title> <p>Eotaxins and their receptor CCR3 have a definitive role for tissue accumulation of eosinophils both under homeostatic and pathologic conditions. However, physiological stimuli that can up‐regulate CCR3 in blood‐derived human eosinophils have not been recognized. As a prior gene microarray study revealed up‐regulation of CCR3 in eosinophils stimulated with retinoic acids (RAs), the expression of functional CCR3 was examined. We found that 9‐cis RA and all‐trans RA (ATRA) significantly induced surface CCR3 expression regardless of the presence of IL‐3 or IL‐5. Pharmacological manipulations with receptor‐specific agonists and antagonists indicated that retinoic acid receptor‐α activation is critical for CCR3 up‐regulation. RA‐induced CCR3 was associated with its functional capacity, in terms of the calcium mobilization and chemotactic response to eotaxin‐1 (CCL11). Our study suggests an important role of vitamin A derivatives in the tissue accumulation of eosinophils.</p> </abstract>