Elevated vascular γ‐butyrobetaine levels attenuate the development of high glucose‐induced endothelial dysfunction. (29th July 2013)

• Record Type: Journal Article
• Authors: Vilskersts, Reinis; Zharkova‐Malkova, Olga; Mezhapuke, Rudolfs; Grinberga, Solveiga; Cirule, Helena; Dambrova, Maija
• Is Part Of: Clinical and experimental pharmacology and physiology. Volume 40:Number 8(2013:Aug.)
• Page Start: 518
• Page End: 524
• Publication Date: 2013-07-29
• Subjects: Clinical pharmacology -- Periodicals; Pharmacology, Experimental -- Periodicals; Physiology, Experimental -- Periodicals; Physiology, Pathological -- Periodicals; 615.1
• DOI: 10.1111/1440-1681.12127
• Languages: English
• ISSNs: 0305-1870

Abstract

<abstract abstract-type="main" id="cep12127-abs-0001"> <title>Summary</title> <p> <list id="cep12127-list-0001" list-type="order"> <list-item> <p>The aim of the present study was to investigate the effects of vascular tissue levels of <sc>l</sc>‐carnitine and its precursor, γ‐butyrobetaine (GBB), on the development of endothelial dysfunction induced by 5 μmol/L lysophosphatidylcholine (LPC), 10 mmol/L triglycerides (TG) or a high glucose concentration (44 mmol/L).</p> </list-item> <list-item> <p>Changes in vascular tissue levels of <sc>l</sc>‐carnitine and GBB were induced by administration of <sc>l</sc>‐carnitine (100 mg/kg), mildronate (100 mg/kg; an inhibitor of <sc>l</sc>‐carnitine synthesis) or their combination to male Wistar rats for 2 weeks.</p> </list-item> <list-item> <p>Treatment with <sc>l</sc>‐carnitine elevated vascular tissue levels of <sc>l</sc>‐carnitine, whereas administration of mildronate reduced <sc>l</sc>‐carnitine levels and increased GBB levels. Experimental animals that received the combination of both drugs showed elevated tissue levels of GBB.</p> </list-item> <list-item> <p>The results from organ bath experiments demonstrated that increased GBB levels with preserved <sc>l</sc>‐carnitine content in vascular tissues attenuated the development of endothelial dysfunction induced by high glucose. However, changes in vascular tissue <sc>l</sc>‐carnitine and GBB levels had no impact on endothelial dysfunction induced by TG or LPC.</p> </list-item> <list-item> <p>The results demonstrate that increased levels of GBB with preserved <sc>l</sc>‐carnitine content in vascular tissue attenuate the development of endothelial dysfunction induced by high glucose concentrations.</p> </list-item> </list> </p> </abstract>