Role of pituitary dysfunction on cardiovascular risk in primary empty sella patients. (6th May 2013)

• Record Type: Journal Article
• Authors: Colao, Annamaria; Cotta, Oana R.; Ferone, Diego; Torre, Maria L.; Ferraù, Francesco; Di, Carolina; Boschetti, Mara; Teti, Claudia; Savanelli, Maria C.; Alibrandi, Angela; Trimarchi, Francesco; Cannavò, Salvatore
• Is Part Of: Clinical endocrinology. Volume 79:Number 2(2013:Aug.)
• Page Start: 211
• Page End: 216
• Publication Date: 2013-05-06
• Subjects: Endocrinology -- Periodicals; 616.4005
• DOI: 10.1111/cen.12122
• Languages: English
• ISSNs: 0300-0664

Abstract

<abstract abstract-type="main" id="cen12122-abs-0001"> <title>Summary</title> <sec id="cen12122-sec-0001" sec-type="section"> <title>Objective</title> <p>Primary empty sella (PES) is a frequent anatomical condition rarely causing pituitary dysfunction. We assessed cardiovascular risk in a cohort of PES patients referred to Endocrine Units.</p> </sec> <sec id="cen12122-sec-0002" sec-type="section"> <title>Design</title> <p>The study was performed in three Italian tertiary referral centres. We evaluated pituitary function and cardiovascular risk, on the basis of lipid and glucose metabolism parameters and of Framingham score (FS), in 94 consecutive patients with PES diagnosis and in 94 gender, age and BMI matched controls.</p> </sec> <sec id="cen12122-sec-0003" sec-type="section"> <title>Patients</title> <p>Pituitary function was normal in 30 patients (<italic>group A</italic>), whereas a single or multiple pituitary hormone deficiency was demonstrated in 64 (<italic>group B</italic>). Growth hormone deficiency (GHD) was diagnosed in 56, central hypothyroidism in 35, hypogonadotropic hypogonadism in 32 and central hypoadrenalism in 24 cases.</p> </sec> <sec id="cen12122-sec-0004" sec-type="section"> <title>Results</title> <p>Framingham score was higher and glucose and lipid profile were worse in PES patients than in controls. Cardiovascular risk parameters were not different between <italic>group A</italic> and <italic>B</italic>. In <italic>group B</italic>, increased cardiovascular risk was associated with hypothyroidism and hypogonadism, but not with GHD. In g<italic>roup A, </italic> cardiovascular risk was higher and FT3 and FT4 levels were lower than in controls. Moreover, PES patients stratified for BMI showed a worse glucose and lipid profile and (in the overweight subgroup) higher FS than matched controls.</p> </sec> <sec id="cen12122-sec-0005" sec-type="section"> <title>Conclusions</title> <p>Primary empty sella patients show increased cardiovascular risk, regardless of BMI. A worse lipid and glucose profile and higher FS were associated with secondary hypothyroidism, even subclinical, as well as hypogonadism.</p> </sec> </abstract>