Intermediate‐term outcome of single kidney grafts from pediatric donors weighing 10–14 kg in adult recipients. (26th March 2013)

• Record Type: Journal Article
• Authors: Gröschl, Isabel; Wolff, Thomas; Gürke, Lorenz; Eugster, Thomas; Hopfer, Helmut; Steiger, Jürg; Schaub, Stefan; Burkhalter, Felix
• Is Part Of: Clinical transplantation. Volume 27:Number 3(2013:May/Jun.)
• Page Start: E302
• Page End: E307
• Publication Date: 2013-03-26
• Subjects: Transplantation of organs, tissues, etc -- Periodicals; 617.95
• DOI: 10.1111/ctr.12115
• Languages: English
• ISSNs: 0902-0063

Abstract

<abstract abstract-type="main" xml:lang="en" id="ctr12115-abs-0001"> <title>Abstract</title> <sec id="ctr12115-sec-0001" sec-type="section"> <title>Background</title> <p>Kidneys from pediatric donors weighing <10 kg are preferably transplanted en bloc, while kidneys from donors weighing >15 kg can be safely transplanted as single kidneys. However, single kidney transplantation from donors weighing 10–14 kg is controversial and has not been well investigated.</p> </sec> <sec id="ctr12115-sec-0002" sec-type="section"> <title>Methods</title> <p>We analyzed the outcome of 15 recipients of single kidneys from donors weighing 10–14 kg (study group) with 40 recipients receiving an allograft from ideal deceased donors (control group).</p> </sec> <sec id="ctr12115-sec-0003" sec-type="section"> <title>Results</title> <p>After a follow‐up of three yr, death‐censored graft survival was 100% in both groups. The calculated creatinine clearance was lower in the study group at six months (53 vs. 71 mL/min; p = 0.01) and similar at 12 months (68 vs. 68 mL/min; p = 0.48), 24 months (81 vs. 70 mL/min; p = 0.58), and 36 months (74 vs. 69 mL/min; p = 0.59). Urinary albumin/creatinine ratios were comparable between the two groups up to two yr. At three yr, urinary albumin/creatinine ratios were higher in the study group than the control group (10.5 vs. 0.9 mg/mmol; p = 0.007). Surveillance biopsies at three and six months post‐transplant revealed no evidence for focal segmental glomerulosclerosis in the study group.</p> </sec> <sec id="ctr12115-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Transplantation of single pediatric kidneys from donors weighing 10–14 kg into adult recipients provides excellent intermediate‐term outcomes. Low‐grade albuminuria, three yr post‐transplant, might indicate late‐onset hyperfiltration injury.</p> </sec> </abstract>