Relationship between apnoea-hypopnoea index and angiographic 
coronary disease phenotypes in patients presenting with acute 
myocardial infarction. (June 2013)

• Record Type: Journal Article
• Authors: Hein, Thet; Loo, Germaine; Ng, Wai-Yee; Tai, Bee-Choo; Kajiya, Takashi; Tan, Adeline; Khoo, See-Meng; Chan, Mark; Low, Adrian F.; Chia, Boon-Lock; Richards, Mark; Lee, Chi-Hang
• Is Part Of: Acute cardiac care. Volume 15:Number 2(2013)
• Page Start: 26
• Page End: 33
• Publication Date: 2013-06
• Subjects: Cardiac intensive care -- Periodicals; Cardiovascular system -- Diseases -- Treatment -- Periodicals; 616.12028
• DOI: 10.3109/17482941.2012.741249
• Languages: English
• ISSNs: 1748-2941

Abstract

<abstract> <title>Abstract</title> <p> <italic>Background:</italic> Relationship between obstructive sleep apnoea and atherosclerosis has not been confirmed using coronary angiography. We sought to investigate the relationships between the apnoea-hypopnoea index (AHI) and angiographic coronary disease phenotypes.</p> <p> <italic>Methods:</italic> SYNTAX score, lesion complexity, and thrombus burden grade were determined in 125 patients presenting with acute myocardial infarction and had undergone a screening sleep study. Severe OSA was defined as AHI ≥ 30. </p> <p> <italic>Results:</italic> Most of the recruited patients were male (97.6%). Severe obstructive sleep apnoea was diagnosed in 37% of the patients. The severe obstructive sleep apnoea group (<italic>n</italic> = 46) was older (<italic>P</italic> = 0.039) and more obese (<italic>P</italic> = 0.003) than the non-severe group (<italic>n</italic> = 79). There was no evidence of difference between the severe and non-severe obstructive sleep apnoea groups with regard to SYNTAX score (<italic>P</italic> = 0.871), number of complex lesions (P = 0.241), and thrombus burden grade (<italic>P</italic> = 0.433). Multivariate analysis adjusting for difference in age and body mass index did not change the findings.</p> <p> <italic>Conclusion:</italic> Using the three angiographic scoring systems, we found no association between AHI and angiographic coronary disease phenotypes, suggesting a limited effect of obstructive sleep apnoea on the amount and distribution of coronary plaques in patients presenting with acute myocardial infarction.</p> </abstract>