Circumcision and penile human papillomavirus prevalence in human immunodeficiency virus‐infected men: heterosexual and men who have sex with men. (8th June 2012)

• Record Type: Journal Article
• Authors: Canadas, M. P.; Darwich, L.; Videla, S.; Sirera, G.; Coll, J.; Rafael, M.‐L. A.; Clotet, B.
• Is Part Of: Clinical microbiology and infection. Volume 19:Number 7(2013:Jul.)
• Page Start: 611
• Page End: 616
• Publication Date: 2012-06-08
• Subjects: Medical microbiology -- Periodicals; Diagnostic microbiology -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 616.01
• DOI: 10.1111/j.1469-0691.2012.03911.x
• Languages: English
• ISSNs: 1198-743X

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Male circumcision is associated with a lower risk of penile human papillomavirus (HPV) infection in human immunodeficiency virus (HIV) uninfected men. Few studies have evaluated the role of male circumcision in penile HPV infection in HIV‐infected men. The aim of this cross‐sectional study was to examine the association between male circumcision and the prevalence of penile HPV infection among HIV‐infected men—both men who have sex with men (MSM) and heterosexual men. Samples from 706 consecutive men included in the CARH‐MEN cohort (overall 24% circumcised: 26% of MSM, 18% of heterosexual men) were examined by Multiplex‐PCR. In the overall group (all HIV‐infected men included), the prevalence of any penile HPV infection was 22% in circumcised men and 27% in uncircumcised men (OR = 1.0, 95% CI 0.6–1.6, adjusted analysis). In the circumcised group the overall prevalence of HPV infection was 22% in MSM and 24% in the heterosexual men, whereas in the uncircumcised group the prevalence was 26% and 28%, respectively. The prevalence of high‐risk HPV types tended to be lower in the circumcised MSM (14% vs 21%, OR = 0.6, 95% CI 0.3–1.1, p 0.088), but it was similar in the heterosexual men (18% in circumcised vs 20% in uncircumcised). These results suggest that male circumcision may be associated with a lower prevalence of oncogenic high‐risk penile HPV infection in HIV‐infected MSM.</p> </abstract>