HO‐1 As Modulator of the Innate Immune Response in Pregnancy. (22nd March 2013)

• Record Type: Journal Article
• Authors: Kahlo, Kristina; Fill Malfertheiner, Sara; Ignatov, Tanja; Jensen, Federico; Costa, Serban‐Dan; Schumacher, Anne; Zenclussen, Ana C.
• Is Part Of: American journal of reproductive immunology. Volume 70:Number 1(2013:Jul.)
• Page Start: 24
• Page End: 30
• Publication Date: 2013-03-22
• Subjects: Human reproduction -- Immunological aspects -- Periodicals; 616.69206
• DOI: 10.1111/aji.12115
• Languages: English
• ISSNs: 1046-7408

Abstract

<abstract abstract-type="main" id="aji12115-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="aji12115-sec-0001" sec-type="section"> <title>Problem</title> <p>The immune modulatory effect of heme oxygenase‐1 (HO‐1) is well documented in studies about sepsis and transplantation. This work evaluates the influence of HO‐1 on the innate immune response during pregnancy.</p> </sec> <sec id="aji12115-sec-0002" sec-type="section"> <title>Method of Study</title> <p>Human first‐trimester trophoblasts derived from normal pregnancies or spontaneous abortions were analyzed for their basal HO‐1, BCL‐associated athanogene‐1 (Bag‐1), and cytokine production before and after LPS treatment. <italic>In vivo</italic>, pregnant <italic>Hmox1<sup>+/+</sup></italic> and <italic>Hmox1<sup>+/−</sup></italic> female mice were treated with LPS, and the production of Bag‐1 was evaluated.</p> </sec> <sec id="aji12115-sec-0003" sec-type="section"> <title>Results</title> <p>Human trophoblasts up‐regulated the expression of both HO‐1 and pro‐inflammatory cytokines after LPS treatment, whereas the basal level of HO‐1 was higher in normal pregnancies. <italic>In vivo</italic>, HO‐1 deficiency provoked diminished Bag‐1 level upon LPS treatment.</p> </sec> <sec id="aji12115-sec-0004" sec-type="section"> <title>Conclusion</title> <p>HO‐1 deficiency causes an inflammatory immune reaction and diminished expression of protective molecules in trophoblasts. Thus, HO‐1 emerges as one important modulator of innate immune responses in pregnancy.</p> </sec> </abstract>