Genotoxicity induced by Taenia solium and its reduction by immunization with calreticulin in a hamster model of taeniosis. (24th May 2013)

• Record Type: Journal Article
• Authors: Salazar, Ana María; Mendlovic, Fela; Cruz‐Rivera, Mayra; Chávez‐Talavera, Oscar; Sordo, Monserrat; Avila, Guillermina; Flisser, Ana; Ostrosky‐Wegman, Patricia
• Is Part Of: Environmental and molecular mutagenesis. Volume 54:Number 5(2013:Jun.)
• Page Start: 347
• Page End: 353
• Publication Date: 2013-05-24
• Subjects: Mutagenesis -- Periodicals; Molecular genetics -- Periodicals; Mutagenèse -- Périodiques; Mutagenèse chimique -- Périodiques; Mutation -- Périodiques; Maladies de l'environnement -- Périodiques; Génétique moléculaire -- Périodiques; 576.542
• DOI: 10.1002/em.21782
• Languages: English
• ISSNs: 0893-6692

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Genotoxicity induced by neurocysticercosis has been demonstrated in vitro and in vivo in humans. The adult stage of <italic>Taenia solium</italic> lodges in the small intestine and is the main risk factor to acquire neurocysticercosis, nevertheless its carcinogenic potential has not been evaluated. In this study, we determined the genotoxic effect of <italic>T. solium</italic> infection in the hamster model of taeniosis. In addition, we assessed the effect of oral immunization with recombinant <italic>T. solium</italic> calreticulin (rTsCRT) plus cholera toxin as adjuvant on micronuclei induction, as this protein has been shown to induce 33–44% protection in the hamster model of taeniosis. Blood samples were collected from the orbital venous plexus of noninfected and infected hamsters at different days postinfection, as well as from orally immunized animals, to evaluate the frequency of micronucleated reticulocytes as a measure of genotoxicity induced by parasite exposure and rTsCRT vaccination. Our results indicate that infection with <italic>T. solium</italic> caused time‐dependent DNA damage in vivo and that rTsCRT immunization reduced the genotoxic damage induced by the presence of the tapeworms. Environ. Mol. Mutagen. 54:347–353, 2013. © 2013 Wiley Periodicals, Inc.</p> </abstract>