Early extensive viremia, but not rs8099917 genotype, is the only predictor for cholestatic hepatitis C after living‐donor liver transplantation. Issue 6 (12th November 2012)

• Record Type: Journal Article
• Authors: Ikegami, Toru; Shirabe, Ken; Fukuhara, Takasuke; Furusyo, Norihiro; Kotoh, Kazuhiro; Kato, Masaki; Shimoda, Shinji; Aishima, Shinichi; Soejima, Yuji; Yoshizumi, Tomoharu; Maehara, Yoshihiko
• Is Part Of: Hepatology research. Volume 43:Issue 6(2013:Jun.)
• Page Start: 621
• Page End: 629
• Publication Date: 2012-11-12
• Subjects: Liver -- Diseases -- Periodicals; Liver Diseases -- Periodicals; Foie -- Maladies -- Périodiques; 616.362
• DOI: 10.1111/hepr.12003
• Languages: English
• ISSNs: 1386-6346

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="hepr12003-sec-0001" sec-type="section"> <title>Aim</title> <p>Cholestatic hepatitis C is one of the most serious but still unaddressed disorders after liver transplantation.</p> </sec> <sec id="hepr12003-sec-9001" sec-type="section"> <title>Methods</title> <p>In this study, we analyzed 49 patients who underwent living‐donor liver transplantation (LDLT) to treat hepatitis C virus (HCV) infection.</p> </sec> <sec id="hepr12003-sec-0002" sec-type="section"> <title>Results</title> <p>Five patients developed cholestatic hepatitis C, with total bilirubin of 15.2 ± 3.1 mg/dL at diagnosis 6.2 ± 1.0 weeks after LDLT. Univariate analysis showed that larger graft to standard liver volume ratio, higher HCV RNA titer at 2 weeks, earlier peak HCV RNA titer and cytomegalovirus infection were the significant risk factors. The development of cholestatic hepatitis C was not significantly associated with interleukin‐28B genotype (rs8099917); four out of five affected patients had the T/T genotype. Multivariate analysis showed that higher HCV RNA titer at 2 weeks was the only significant factor (<italic>P</italic> = 0.026) for the development of cholestatic hepatitis C. Receiver–operator curve analysis showed that that HCV RNA titer of more than 7.2 log<sub>10</sub>IU/mL was the optimal cut‐off for characterizing cholestatic hepatitis C. All of the patients were serum HCV RNA negative after treatment with pegylated interferon and ribavirin and all the patients are alive.</p> </sec> <sec id="hepr12003-sec-0003" sec-type="section"> <title>Conclusion</title> <p>Early extensive viremia, but not the rs8099917 genotype, was the only predictor for cholestatic hepatitis C after LDLT.</p> </sec> </abstract>