Similar Ethanol Drinking in Adolescent and Adult C57BL/6J Mice After Chronic Ethanol Exposure and Withdrawal. (8th January 2013)

• Record Type: Journal Article
• Authors: Carrara‐Nascimento, Priscila F.; Lopez, Marcelo F.; Becker, Howard C.; Olive, M. Foster; Camarini, Rosana
• Is Part Of: Alcoholism. Volume 37:Number 6(2013:Jun.)
• Page Start: 961
• Page End: 968
• Publication Date: 2013-01-08
• Subjects: Alcoholism -- Periodicals; Alcoholism -- Periodicals; Alcoolisme; Electronic journals; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.861005
• DOI: 10.1111/acer.12056
• Languages: English
• ISSNs: 0145-6008

Abstract

<abstract abstract-type="main" xml:lang="en" id="acer12056-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="acer12056-sec-0001" sec-type="section"> <title>Background</title> <p>Increasing evidence shows that excessive alcohol consumption during adolescence increases vulnerability to alcohol use disorders in adulthood. The aim of this study was to examine differences between adolescent and adult C57BL/6J mice in drinking behavior and blood ethanol (EtOH) concentrations (BECs) after chronic EtOH exposure and withdrawal.</p> </sec> <sec id="acer12056-sec-0002" sec-type="section"> <title>Methods</title> <p>Male adolescent (PND = 28 to 30) and adult (PND = 70) C57BL/6J mice were allowed to consume EtOH in a 2‐bottle choice paradigm (15% EtOH vs. water) for 3 weeks (Baseline drinking, Test 1, and Test 2), which were interspersed with 2 cycles (Cycles I and II) of chronic EtOH vapor or air inhalation (16 hours) and withdrawal (8 hours). BECs were determined during both cycles.</p> </sec> <sec id="acer12056-sec-0003" sec-type="section"> <title>Results</title> <p>Chronic EtOH exposure led to increased EtOH intake during Test 1 and Test 2 in both adolescent and adult mice compared with air‐exposed controls, and no differences between age groups were observed. During Cycle I adult mice showed higher BECs compared with adolescents. During Cycle II, BECs were lower in adult mice as compared to Cycle I, and BECs in adolescent mice did not change between the 2 cycles.</p> </sec> <sec id="acer12056-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Chronic EtOH exposure followed by withdrawal periods increases EtOH consumption similarly in both adolescent and adult mice, despite differences in BECs.</p> </sec> </abstract>