Fractal structure determines controlled release kinetics of monolithic osmotic pump tablets. (14th March 2013)

• Record Type: Journal Article
• Authors: Yin, Xianzhen; Li, Haiyan; Liu, Ruihao; Chen, Jing; Ji, Junqiu; Chen, Jun; Shao, Qun; Xiao, Tiqiao; York, Peter; He, You; Zhang, Jiwen
• Is Part Of: Journal of pharmacy and pharmacology. Volume 65:Number 7(2013:Jul.)
• Page Start: 953
• Page End: 959
• Publication Date: 2013-03-14
• Subjects: Pharmacy -- Periodicals; Pharmacology -- Periodicals; 615.1
• DOI: 10.1111/jphp.12056
• Languages: English
• ISSNs: 0022-3573

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="jphp12056-sec-0001" sec-type="section"> <title>Objectives</title> <p>To calculate the fractal dimension values of felodipine osmotic pump tablets during drug dissolution and to characterize the mechanism of the controlled drug release kinetics through three‐dimensional fractal data.</p> </sec> <sec id="jphp12056-sec-0002" sec-type="section"> <title>Methods</title> <p>Three‐dimensional fractal values of volume (D<sub><italic>f</italic>, volume</sub>) and surface (D<sub><italic>f</italic>, surface</sub>) of the tablet core were calculated based on the box counting method.</p> </sec> <sec id="jphp12056-sec-0003" sec-type="section"> <title>Key findings</title> <p>During the process of release of felodipine, both D<sub><italic>f</italic>, volume</sub> and D<sub><italic>f</italic>, surface</sub> were within the range of 2–3 and then changed markedly after a period of 3.0 h release, corresponding to extensive changes in entire shape, interior porous channels and surface structure of the tablet core. The curve of D<sub><italic>f</italic>, volume</sub> mirrored that for tablet volume, however the curve of D<sub><italic>f</italic>, surface</sub> was quite different from that of the surface area. Results showed that values of D<sub><italic>f</italic>, surface</sub> correlated well with the drug release rate. D<sub><italic>f</italic>, surface</sub> was found to be an efficient fractal parameter that could be used to characterize the complex changes to the tablet core that take place during drug release.</p> </sec> <sec id="jphp12056-sec-0004" sec-type="section"> <title>Conclusions</title> <p>The fractal dimension can be used as a quantitative indicator reflecting the drug release performance and be regarded as a key indicator for the quality control of oral controlled drug delivery systems.</p> </sec> </abstract>