Emerging non-canonical functions for heterotrimeric G proteins in cellular signaling. (June 2013)

• Record Type: Journal Article
• Authors: Ahmed, Syed M.; Angers, Stephane
• Is Part Of: Journal of receptor and signal transduction research. Volume 33:Number 3(2013)
• Page Start: 177
• Page End: 183
• Publication Date: 2013-06
• Subjects: Cell receptors -- Periodicals; Cellular signal transduction -- Periodicals; 571.6
• DOI: 10.3109/10799893.2013.795972
• Languages: English
• ISSNs: 1079-9893

Abstract

<abstract> <title>Abstract</title> <p>Classically heterotrimeric G proteins have been described as the principal signal transducing machinery for G-protein-coupled receptors. Receptor activation catalyzes nucleotide exchange on the Gα protein, enabling Gα-GTP and Gβγ-subunits to engage intracellular effectors to generate various cellular effects such as second messenger production or regulation of ion channel conductivity. Recent genetic and proteomic screens have identified novel heterotrimeric G-protein-interacting proteins and expanded their functional roles. This review highlights some examples of recently identified interacting proteins and summarizes how they functionally connect heterotrimeric G proteins to previously underappreciated cellular roles.</p> </abstract>