The kinin–kallikrein system: physiological roles, pathophysiology and its relationship to cancer biomarkers. (June 2013)

• Record Type: Journal Article
• Authors: Kashuba, Elena; Bailey, James; Allsup, David; Cawkwell, Lynn
• Is Part Of: Biomarkers. Volume 18:Number 4(2013)
• Page Start: 279
• Page End: 296
• Publication Date: 2013-06
• Subjects: Biochemical markers -- Periodicals; 610.28
• DOI: 10.3109/1354750X.2013.787544
• Languages: English
• ISSNs: 1354-750X

Abstract

<abstract> <title>Abstract</title> <p>The kinin–kallikrein system (KKS) is an endogenous multiprotein cascade, the activation of which leads to triggering of the intrinsic coagulation pathway and enzymatic hydrolysis of kininogens with the consequent release of bradykinin-related peptides. This system plays a crucial role in inflammation, vasodilation, smooth muscle contraction, cardioprotection, vascular permeability, blood pressure control, coagulation and pain. In this review, we will outline the physiology and pathophysiology of the KKS and also highlight the association of this system with carcinogenesis and cancer progression.</p> </abstract>