Atopy phenotypes in the Childhood Asthma Prevention Study (CAPS) cohort and the relationship with allergic disease. Issue 6 (28th May 2013)

• Record Type: Journal Article
• Authors: Garden, F. L.; Simpson, J. M.; Marks, G. B.
• Is Part Of: Clinical & experimental allergy. Volume 43:Issue 6(2013:Jun.)
• Page Start: 633
• Page End: 641
• Publication Date: 2013-05-28
• Subjects: Allergy -- Periodicals; Immunology -- Periodicals; 616.97
• DOI: 10.1111/cea.12095
• Languages: English
• ISSNs: 0954-7894

Abstract

<abstract abstract-type="main" xml:lang="en" id="cea12095-abs-0002"> <title>Summary</title> <sec id="cea12095-sec-0001" sec-type="section"> <title>Background</title> <p>Atopy in early life is heterogeneous in timing of onset, remission and persistence and in the nature of specific sensitization to allergens. However, this heterogeneity is not well characterized.</p> </sec> <sec id="cea12095-sec-0002" sec-type="section"> <title>Objective</title> <p>Our aim was to define longitudinal phenotypes of atopy between ages 1.5 and 8 years, and to assess the relationship of the atopy phenotypes to the risk of asthma, eczema and rhinitis at 8 years of age.</p> </sec> <sec id="cea12095-sec-0003" sec-type="section"> <title>Methods</title> <p>We used latent class analysis (LCA) to define atopy phenotypes using data from skin prick tests that were performed at 1.5, 3, 5 and 8 years in participants in the Childhood Asthma Prevention Study (CAPS).</p> </sec> <sec id="cea12095-sec-0004" sec-type="section"> <title>Results</title> <p>Four phenotypes were defined: late mixed inhalant sensitization; mixed food and inhalant sensitization; house dust mite (HDM) monosensitized; and no atopy. All three atopic phenotypes were associated with asthma, eczema and rhinitis, but the strongest association, particularly for asthma, was with the mixed food and inhalant sensitization phenotype.</p> </sec> <sec id="cea12095-sec-0005" sec-type="section"> <title>Conclusion & clinical relevance</title> <p>We have used a LCA model to define atopy phenotypes empirically. The finding of a strong association between the mixed food and inhalant sensitization class and the presence of asthma and poor asthma control at age 8 years implies that food sensitization in early life may be of greater significance for subsequent risk of asthma than previously thought.</p> </sec> </abstract>