EGFR, KRAS, BRAF, and HER‐2 molecular status in brain metastases from 77 NSCLC patients. (23rd April 2013)

• Record Type: Journal Article
• Authors: Villalva, Claire; Duranton‐Tanneur, Valérie; Guilloteau, Karline; Burel‐Vandenbos, Fanny; Wager, Michel; Doyen, Jérôme; Levillain, Pierre Marie; Fontaine, Denys; Blons, Hélène; Pedeutour, Florence; Karayan‐Tapon, Lucie
• Is Part Of: Cancer medicine. Volume 2:Number 3(2013:Jun.)
• Page Start: 296
• Page End: 304
• Publication Date: 2013-04-23
• Subjects: 616.994005
• DOI: 10.1002/cam4.82
• Languages: English
• ISSNs: 2045-7634

Abstract

<abstract abstract-type="main" xml:lang="en" id="cam482-abs-0001"> <title>Abstract</title> <p>The aim of this study was to determine the frequency of <italic>EGFR, KRAS</italic>, <italic> BRAF, </italic> and <italic>HER‐</italic>2 mutations in brain metastases from non‐small cell lung carcinomas (BM‐NSCLC). A total of 77 samples of BM‐NSCLC were included and 19 samples of BM from breast, kidney, and colorectal tumors were also studied as controls. These samples were collected from patients followed between 2008 and 2011 at Poitiers and Nice University Hospitals in France. The frequencies of <italic>EGFR</italic>, <italic> KRAS</italic>, <italic> BRAF, </italic> and <italic>HER‐</italic>2 mutations in BM‐NSCLC were 2.6, 38.5, 0, and 0% respectively. The incidence of <italic>KRAS</italic> mutation was significantly higher in female and younger patients (<italic>P</italic> < 0.05). No mutations of the four genes were found in BM from breast or kidney. However, among six BM from colorectal tumors, we identified <italic>KRAS</italic> mutations in three cases and <italic>BRAF</italic> mutations in two other cases. This study is the largest analysis on genetic alterations in BM‐NSCLC performed to date. Our results suggest a low frequency of <italic>EGFR</italic> mutations in BM‐NSCLC whereas <italic>KRAS</italic> mutations are as frequent in BM‐NSCLC as in primitive NSCLC. These results raise the question of the variability of the brain metastatic potential of NSCLC cells in relation to the mutation pattern.</p> </abstract>