Anti-gastritis and wound healing effects of Momordicae Semen extract and its active component. (February 2013)

• Record Type: Journal Article
• Authors: Jung, Kiwon; Chin, Young-Won; Chung, Yoon Hee; Park, Yang Hae; Yoo, Hunseung; Min, Dong Sun; Lee, Bongyong; Kim, Jinwoong
• Is Part Of: Immunopharmacology and immunotoxicology. Volume 35:Number 1(2013:Feb.)
• Page Start: 126
• Page End: 132
• Publication Date: 2013-02
• Subjects: Immunopharmacology -- Periodicals; Immunotoxicology -- Periodicals; Antibody-toxin conjugates -- Periodicals; Immunology -- Periodicals; 615.37
• DOI: 10.3109/08923973.2012.712139
• Languages: English
• ISSNs: 0892-3973

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p>Momordicae Semen, <italic>Momordica cochinchinensis</italic> Springer (Cucurbitaceae), has long been known to effectively relieve boils, rheumatic pain, and hemorrhoids. In this study, we investigated whether Momordicae Semen extract (MSE) has anti-gastritis effects in various rodent models and also explored possible mechanisms for the gastroprotective effects of MSE. MSE provided remarkable protective effects, comparable to those of rebamipide, in ethanol- and diclofenac-induced acute gastritis. In addition, it has demonstrated protective effect in a <italic>Helicobacter pylori</italic>-insulted chronic gastritis model. MSE also showed wound healing effect on cutaneous injury of mice and stimulated calcitonin gene-related peptide and somatostatin receptors, which may be related to its anti-gastritis effects. In a single oral dose toxicity study, the approximate lethal dose of MSE was determined at &gt;2000 mg/kg/day. The NOAEL was set to be 2000 mg/kg/day from the repeated oral dose toxicity study. Moreover, momordica saponin I, a major ingredient of MSE, treatment decreased gastric mucosa damage indices in the ethanol- and diclofenac-induced acute gastritis models. The results suggest that MSE could be a promising gastroprotective herbal medicine and momordica saponin I might be used as an active marker compound for MSE.</p> </abstract>