Subcutaneous Panniculitis-Like T-Cell Lymphoma in Two Pediatric Patients: An HIV-Positive Adolescent and a 4-Month-Old Infant. (1st June 2013)

• Record Type: Journal Article
• Authors: Acree, Sara C.; Tovar, Jason P.; Pattengale, Paul K.; Wang, Larry L.; Church, Joseph A.; Gaynon, Paul S.; Cassarino, David S.
• Is Part Of: Fetal and pediatric pathology. Volume 32:Number 3(2013)
• Page Start: 175
• Page End: 183
• Publication Date: 2013-06-01
• Subjects: Pathology, Molecular -- Periodicals; Pediatrics -- Periodicals; Molecular biology -- Periodicals; Pediatric pathology -- Periodicals; Fetal Diseases -- pathology -- Periodicals; Infant, Newborn, Diseases -- pathology -- Periodicals; Pediatrics -- Periodicals; 618.92007
• DOI: 10.3109/15513815.2012.701264
• Languages: English
• ISSNs: 1551-3815

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p>Subcutaneous Panniculitis-like T-cell lymphoma (SPTCL) is a rare subtype of childhood non-Hodgkin lymphoma. Subcutaneous Panniculitis-like T-cell lymphoma has an aggressive variant associated with the hemophagocytic syndrome (HPS). Patients without HPS show resolution of the disease with prednisone or immunosuppressive therapy unlike other T-cell lymphomas. One HIV-positive adolescent and one infant with multiple subcutaneous masses are presented and the literature is reviewed. Lesional cells were consistent with SPTCL alpha-beta type. Our cases, without HPS, showed complete resolution of their lesions when treated with non-aggressive therapies. Patients with SPTCL alpha-beta should be treated conservatively.</p> </abstract>