A pilot study examining short-term changes in bone mineral density among class 3 obese users of depot-medroxyprogesterone acetate. (June 2013)

• Record Type: Journal Article
• Authors: Segall-Gutierrez, Penina; Agarwal, Reshem; Ge, Marshall; Lopez, Claudia; Hernandez, Gerson; Stanczyk, Frank Z.
• Is Part Of: European journal of contraception & reproductive health care. Volume 18:Number 3(2013:Jun.)
• Page Start: 199
• Page End: 205
• Publication Date: 2013-06
• Subjects: Contraception -- Periodicals; Reproductive health -- Periodicals; Generative organs, Female -- Periodicals; Contraception -- Periodicals; Reproductive Medicine -- Periodicals; 613.9
• DOI: 10.3109/13625187.2013.774358
• Languages: English
• ISSNs: 1362-5187

Abstract

<abstract> <title>ABSTRACT</title> <p> <bold>Objective</bold> To examine changes in lumbar spine-bone mineral density (LS-BMD) among normal weight (body mass index [BMI] = 18.5–24.9 kg/m<sup>2</sup>), Class 1–2 obese (BMI = 30–39.9 kg/m<sup>2</sup>), and Class 3 obese (BMI ≥ 40 kg/m<sup>2</sup>) women utilising depot-medroxyprogesterone acetate (DMPA).</p> <p> <bold>Methods</bold> Five normal-weight, five Class 1–2 obese, and five Class 3 obese women received subcutaneous injections of DMPA-SC at baseline and 12 weeks later. Dual Energy X-ray Absorptiometry (DEXA) scans were performed at baseline and 18 weeks after the first injection for determination of LS-BMD and analysis of fat content. Bimonthly oestradiol (E<sub>2</sub>) levels were measured by immunoassay methods for 26 weeks.</p> <p> <bold>Results</bold> There were no significant demographic or LS-BMD differences among the three BMI groups. Significant differences at baseline were as expected among the three groups with respect to BMI and associated parameters (mean % total body fat, absolute fat, and weight). When used as their own controls, significant changes in LS-BMD, % body fat and absolute fat determined by DEXA occurred among all three BMI strata. Class 1–2 obese and Class 3 obese women were more likely to experience E<sub>2</sub> fluctuations, but short-term changes in LS-BMD were similar.</p> <p> <bold>Conclusions</bold> DMPA-SC administration affects L-spine bone health similarly regardless of BMI status.</p> </abstract>