Intestinal mucosal MMP-1 – a prognostic factor in colon cancer. (May 2013)

• Record Type: Journal Article
• Authors: Langenskiöld, Marcus; Ivarsson, Marie-Lois; Holmdahl, Lena; Falk, Peter; Kåbjörn-Gustafsson, Christina; Angenete, Eva
• Is Part Of: Scandinavian journal of gastroenterology. Volume 48:Number 5(2013)
• Page Start: 563
• Page End: 569
• Publication Date: 2013-05
• Subjects: Gastroenterology -- Periodicals; Digestive organs -- Diseases -- Periodicals; 616.33
• DOI: 10.3109/00365521.2012.708939
• Languages: English
• ISSNs: 0036-5521

Abstract

<abstract> <title>Abstract</title> <p> <bold> <italic>Objective.</italic> </bold> There is evidence that transforming growth factor-β₁ (TGF-β₁) and matrix metalloproteinases (MMPs) play an important role in tumor invasion and progression in colorectal cancer. The aim of this study was to assess their utility in prediction of cancer-specific survival (CSS). <bold><italic>Materials and methods. </italic></bold>136 patients undergoing curative surgery for colorectal carcinoma were prospectively included. Samples were taken from tumor and tumor-free intestinal mucosa and ELISA was used to assess protein levels in the tissues. Patients were followed for CSS. The median follow-up time for all included patients was 65 months (range: 45–92). The main outcome measure was CSS. <bold><italic>Results.</italic></bold> T stage, lymph node involvement and high levels of MMP-1 as well as MMP-9 in tumor-free mucosa tissue were significantly associated with CSS in colon cancer in univariate analysis. This prognostic strength was maintained for MMP-1 and N-status in multivariate analysis. <bold><italic>Conclusions. </italic></bold>The results indicate that MMP-1 is independently associated with CSS in patients with colon cancer. Furthermore, a possible clinical implication is that MMP-1 protein expression in tumor-free mucosa could identify colon cancer patients with poor CSS in need of more intensified adjuvant treatment.</p> </abstract>